(S)-(5-(2-isopropyl-4-(3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

Base Information

• Chemical Name: (S)-(5-(2-isopropyl-4-(3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
• CAS No.: 1421659-13-3
• Molecular Formula: C₂₃H₂₈N₄O₃
• Molecular Weight: 408.5

Synonyms:(S)-(5-(2-isopropyl-4-(3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

Chemical Property of (S)-(5-(2-isopropyl-4-(3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-(5-(2-isopropyl-4-(3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

There total 2 articles about (S)-(5-(2-isopropyl-4-(3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H28N4O4 → (S)-(5-(2-isopropyl-4-(3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol (1421659-13-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

DOI:10.1016/j.bmc.2018.06.025

Reference yield:

(S)-3-methylmorpholine (350595-57-2) + C17H15N3O4 → (S)-(5-(2-isopropyl-4-(3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol (1421659-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 12 h / Reflux

1.2: 6 h / Reflux

1.3: 12 h / 120 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran;

DOI:10.1016/j.bmc.2018.06.025

upstream raw materials:

(S)-3-methylmorpholine

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