C₄₆H₆₂O₁₃Si

Base Information

Chemical Name:C₄₆H₆₂O₁₃Si
CAS No.:256342-14-0
Molecular Formula:C₄₆H₆₂O₁₃Si
Molecular Weight:851.076
Hs Code.:

C<sub>46</sub>H<sub>62</sub>O<sub>13</sub>Si

Synonyms:C₄₆H₆₂O₁₃Si

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Chemical Property of C₄₆H₆₂O₁₃Si

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Technology Process of C₄₆H₆₂O₁₃Si

There total 43 articles about C₄₆H₆₂O₁₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 256342-13-9
C₄₀H₄₈O₁₃

: 256342-14-0
C₄₆H₆₂O₁₃Si

Guidance literature:: With 18-crown-6 ether; sodium hydride; In tetrahydrofuran; at 0 - 25 ℃; for 4h;
DOI:10.1002/(SICI)1521-3773(19991115)38:22<3340::AID-ANIE3340>3.0.CO;2-2

Reference yield:

: 306726-10-3
(1R,2S,3S)-2,3-Bis-allyloxy-4-(tert-butyl-diphenyl-silanyloxy)-1-thiazol-2-yl-butan-1-ol

: 256342-14-0
C₄₆H₆₂O₁₃Si

Guidance literature:: Multi-step reaction with 26 steps

1.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 - 25 °C

2.1: molecular sieves 4 Angstroem / acetonitrile / 0.25 h / 25 °C

3.1: NaBH₄ / methanol / 0.5 h / 0 °C

3.2: H₂O; CuCl₂; CuO / acetonitrile / 2 h / 25 °C

4.1: 10.97 g / TBAF; AcOH / 2 h / 25 °C

5.1: 85 percent / DBU / CH₂Cl₂ / 0.5 h / 0 °C

6.1: nBu₂SnO / methanol / 3 h / Heating

6.2: TMSOTf / CH₂Cl₂ / 12 h / 0 - 25 °C

6.3: 10.82 g / PPTS; MeOH / 1 h / 25 °C

7.1: 87 percent / NaH / dimethylformamide / 1 h / 0 - 25 °C

8.1: 95 percent / NaOH; MeOH / diethyl ether / 1 h / 25 °C

9.1: NaH / dimethylformamide / 0.08 h / 0 °C

9.2: 90 percent / nBu₄NI / dimethylformamide / 4 h / 0 - 25 °C

10.1: 91 percent / DDQ; H₂O / CH₂Cl₂ / 1 h / 0 - 25 °C

11.1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 - 25 °C

12.1: DABCO / [(Ph₃P)3RhCl] / aq. ethanol / 2 h / Heating

13.1: 9.27 g / NMO; OsO₄; H₂O / acetone / 8 h / 25 °C

14.1: nBu₂SnO / toluene / 3 h / Heating

14.2: toluene / 1 h / 0 - 25 °C

15.1: 96 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 - 25 °C

16.1: 96 percent / Et₃N; MeOH / CH₂Cl₂ / 6 h / 40 °C

17.1: 92 percent / SnCl₂; molecular sieves 4 Angstroem / diethyl ether / 3 h / 0 - 25 °C

18.1: 98 percent / K₂CO₃; MeOH / diethyl ether / 12 h / 25 °C

19.1: aq. NaIO₄; NaHCO₃ / methanol; CH₂Cl₂ / 2 h / 25 °C

20.1: 430 mg / iPr₂NH; vinyl acetate / toluene / 12 h / 140 °C

21.1: 95 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

22.1: 97 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 - 25 °C

23.1: 95 percent / TBAF; AcOH / tetrahydrofuran / 1 h / 25 °C

24.1: 85 percent / Martin sulfurane; Et₃N / CHCl₃ / 2 h / 50 °C

25.1: 90 percent / K₂CO₃; MeOH / 6 h / 25 °C

26.1: NaH; 18-crown-6 / tetrahydrofuran / 0.25 h / 0 °C

26.2: 80 percent / tetrahydrofuran / 2 h / 0 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 2,6-dimethylpyridine; methanol; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; vinyl acetate; N-methyl-2-indolinone; Martins sulfurane; 18-crown-6 ether; 4 A molecular sieve; tetrabutyl ammonium fluoride; water; sodium hydride; di(n-butyl)tin oxide; sodium hydrogencarbonate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tin(ll) chloride; Wilkinson's catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 1.1: Esterification / 2.1: Methylation / 3.1: Reduction / 3.2: Ring cleavage / 4.1: Cyclization / 5.1: Addition / 6.1: Cyclization / 6.2: Ring cleavage / 6.3: Methanolysis / 7.1: Methylation / 8.1: Debenzoylation / 9.1: Metallation / 9.2: Etherification / 10.1: Oxidation / 11.1: Etherification / 12.1: Isomerization / 13.1: Oxidation / 14.1: Cyclization / 14.2: Ring cleavage / 15.1: Esterification / 16.1: Deacylation / 17.1: Glycosidation / 18.1: Debenzoylation / 19.1: Oxidation / 20.1: Cyclizati;
DOI:10.1002/1521-3765(20000901)6:17<3116::AID-CHEM3116>3.0.CO;2-8

Reference yield:

: 306726-12-5
Benzoic acid (1R,2R,3S)-2,3-bis-allyloxy-4-(tert-butyl-diphenyl-silanyloxy)-1-thiazol-2-yl-butyl ester

: 256342-14-0
C₄₆H₆₂O₁₃Si

Guidance literature:: Multi-step reaction with 25 steps

1.1: molecular sieves 4 Angstroem / acetonitrile / 0.25 h / 25 °C

2.1: NaBH₄ / methanol / 0.5 h / 0 °C

2.2: H₂O; CuCl₂; CuO / acetonitrile / 2 h / 25 °C

3.1: 10.97 g / TBAF; AcOH / 2 h / 25 °C

4.1: 85 percent / DBU / CH₂Cl₂ / 0.5 h / 0 °C

5.1: nBu₂SnO / methanol / 3 h / Heating

5.2: TMSOTf / CH₂Cl₂ / 12 h / 0 - 25 °C

5.3: 10.82 g / PPTS; MeOH / 1 h / 25 °C

6.1: 87 percent / NaH / dimethylformamide / 1 h / 0 - 25 °C

7.1: 95 percent / NaOH; MeOH / diethyl ether / 1 h / 25 °C

8.1: NaH / dimethylformamide / 0.08 h / 0 °C

8.2: 90 percent / nBu₄NI / dimethylformamide / 4 h / 0 - 25 °C

9.1: 91 percent / DDQ; H₂O / CH₂Cl₂ / 1 h / 0 - 25 °C

10.1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 - 25 °C

11.1: DABCO / [(Ph₃P)3RhCl] / aq. ethanol / 2 h / Heating

12.1: 9.27 g / NMO; OsO₄; H₂O / acetone / 8 h / 25 °C

13.1: nBu₂SnO / toluene / 3 h / Heating

13.2: toluene / 1 h / 0 - 25 °C

14.1: 96 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 - 25 °C

15.1: 96 percent / Et₃N; MeOH / CH₂Cl₂ / 6 h / 40 °C

16.1: 92 percent / SnCl₂; molecular sieves 4 Angstroem / diethyl ether / 3 h / 0 - 25 °C

17.1: 98 percent / K₂CO₃; MeOH / diethyl ether / 12 h / 25 °C

18.1: aq. NaIO₄; NaHCO₃ / methanol; CH₂Cl₂ / 2 h / 25 °C

19.1: 430 mg / iPr₂NH; vinyl acetate / toluene / 12 h / 140 °C

20.1: 95 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

21.1: 97 percent / Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 - 25 °C

22.1: 95 percent / TBAF; AcOH / tetrahydrofuran / 1 h / 25 °C

23.1: 85 percent / Martin sulfurane; Et₃N / CHCl₃ / 2 h / 50 °C

24.1: 90 percent / K₂CO₃; MeOH / 6 h / 25 °C

25.1: NaH; 18-crown-6 / tetrahydrofuran / 0.25 h / 0 °C

25.2: 80 percent / tetrahydrofuran / 2 h / 0 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 2,6-dimethylpyridine; methanol; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; vinyl acetate; N-methyl-2-indolinone; Martins sulfurane; 18-crown-6 ether; 4 A molecular sieve; tetrabutyl ammonium fluoride; water; sodium hydride; di(n-butyl)tin oxide; sodium hydrogencarbonate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tin(ll) chloride; Wilkinson's catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 1.1: Methylation / 2.1: Reduction / 2.2: Ring cleavage / 3.1: Cyclization / 4.1: Addition / 5.1: Cyclization / 5.2: Ring cleavage / 5.3: Methanolysis / 6.1: Methylation / 7.1: Debenzoylation / 8.1: Metallation / 8.2: Etherification / 9.1: Oxidation / 10.1: Etherification / 11.1: Isomerization / 12.1: Oxidation / 13.1: Cyclization / 13.2: Ring cleavage / 14.1: Esterification / 15.1: Deacylation / 16.1: Glycosidation / 17.1: Debenzoylation / 18.1: Oxidation / 19.1: Cyclization / 20.1: Silyl ether;
DOI:10.1002/1521-3765(20000901)6:17<3116::AID-CHEM3116>3.0.CO;2-8