Chemical Property of Bevantolol hydrochloride
Chemical Property:
- Vapor Pressure:1.44E-11mmHg at 25°C
- Melting Point:137-138°
- Boiling Point:518.3 °C at 760 mmHg
- Flash Point:267.3 °C
- PSA：59.95000
- LogP:3.77710
- Storage Temp.:Sealed in dry,Room Temperature
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:10
- Exact Mass:381.1706861
- Heavy Atom Count:26
- Complexity:355
- Purity/Quality:
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99% *data from raw suppliers
Bevantolol Hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=CC=C1)OCC(CNCCC2=CC(=C(C=C2)OC)OC)O.Cl
- Recent ClinicalTrials:Efficacy and Safety on SOM3355 in Huntington's Disease Chorea
- Recent EU Clinical Trials:Phase IIb, randomized, double-blind, placebo-controlled study in parallel groups assessing the efficacy and safety of two doses of SOM3355 in patients suffering from Huntington’s Disease with choreic movements.
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Description
Bevantolol hydrochloride is a cardioselective (β1) adrenergic blocker, devoid of intrinsic
sympathomimetic and local anesthetic activities. As with other agents of this category, it
is useful in the treatment of hypertension and angina. Bevantolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 14.79 nM in rat cortical membranes). It is selective for β1- over β2-ARs (Ki = 588.84 nM), as well as α2-ARs up to 100 μM, but is an antagonist of α1-ARs (Ki = 125.89 nM). Bevantolol inhibits low voltage-activated calcium currents (LVA-ICa) in dissociated rat ventro-medial hypothalamic neurons (IC50 = 40 μM). It inhibits norepinephrine-induced contraction of isolated rabbit thoracic aorta (pA2 = 4.77), isoprenaline-induced inotropic effects in isolated guinea pig right atria (pA2 = 7.74), and isoprenaline-induced relaxation of isolated guinea pig trachea (pA2 = 6.69). Bevantolol (250 mg/kg per day) prevents immobilization stress-induced increases in systolic blood pressure in a rat model of stress-induced hypertension.
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Uses
Bevantolol is a cardioselective β-adrenergic blocker. Bevantolol is used as an antianginal, antihypertensive, antiarrhythmic.
