(S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

Base Information

Chemical Name:(S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide
CAS No.:88867-90-7
Molecular Formula:C₁₉H₂₁ClN₂O₃S
Molecular Weight:392.906
Hs Code.:

Synonyms:(S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

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Technology Process of (S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

There total 4 articles about (S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 88867-97-4
(S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carbonyl chloride

: 88867-90-7
(S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 50 ℃; for 3h;
DOI:10.1021/ac00270a022

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 88867-90-7
(S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 10percent potassium carbonate / tetrahydrofuran / 3 h / 50 °C

2: thionyl chloride / benzene / 48 h / 35 - 40 °C

3: 10percent potassium carbonate / tetrahydrofuran / 3 h / 50 °C

With thionyl chloride; potassium carbonate; In tetrahydrofuran; benzene;
DOI:10.1021/ac00270a022

Reference yield:

: 73096-27-2,251096-94-3
1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid

: 88867-90-7
(S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / benzene / 48 h / 35 - 40 °C

2: 10percent potassium carbonate / tetrahydrofuran / 3 h / 50 °C

With thionyl chloride; potassium carbonate; In tetrahydrofuran; benzene;
DOI:10.1021/ac00270a022