2-(4-fluorophenyl)-7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine

Base Information

Chemical Name:2-(4-fluorophenyl)-7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine
CAS No.:1385059-58-4
Molecular Formula:C₁₉H₁₄FN₃OS
Molecular Weight:351.404
Hs Code.:

Synonyms:2-(4-fluorophenyl)-7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-fluorophenyl)-7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine

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Technology Process of 2-(4-fluorophenyl)-7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine

There total 3 articles about 2-(4-fluorophenyl)-7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 352-34-1
4-fluoro-1-iodobenzene

: 1385059-70-0
7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine

: 1385059-58-4
2-(4-fluorophenyl)-7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver carbonate; In water; at 60 ℃; for 48h;
DOI:10.1039/c2gc35399g

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1385059-58-4
2-(4-fluorophenyl)-7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 5 h / 100 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver carbonate / water / 48 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; silver carbonate; In water; toluene;
DOI:10.1039/c2gc35399g

Reference yield:

: 13316-09-1
7-chloro-2-methylthiazolo[5,4-d]pyrimidine

: 1385059-58-4
2-(4-fluorophenyl)-7-(4-methoxyphenyl)-5-methylthiazolo[5,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 5 h / 100 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver carbonate / water / 48 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; silver carbonate; In water; toluene;
DOI:10.1039/c2gc35399g