2-(phenylmethylthio)benzenemethanol

Base Information

• Chemical Name: 2-(phenylmethylthio)benzenemethanol
• CAS No.: 4521-45-3
• Molecular Formula: C₁₄H₁₄OS
• Molecular Weight: 230.331
• Mol file: 4521-45-3.mol

Synonyms:2-(phenylmethylthio)benzenemethanol

Chemical Property of 2-(phenylmethylthio)benzenemethanol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(phenylmethylthio)benzenemethanol

There total 13 articles about 2-(phenylmethylthio)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 2-(benzylthio)benzoate (92737-52-5) → 2-(phenylmethylthio)benzenemethanol (4521-45-3)

Guidance literature:

With sodium tetrahydroborate; N,N-dimethyl-aniline; zinc(II) chloride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1246/bcsj.64.2730

Reference yield: 97.0%

2-methoxycarbonyl-1-benzylthiobenzene (58435-43-1) → 2-(phenylmethylthio)benzenemethanol (4521-45-3)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

DOI:10.1016/j.tetlet.2005.03.161

Reference yield: 94.0%

o-bromobenzyl alcohol (18982-54-2) + benzyl bromide (100-39-0) → 2-(phenylmethylthio)benzenemethanol (4521-45-3)

Guidance literature:

o-bromobenzyl alcohol; With tert.-butyl lithium; isopropylmagnesium chloride; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

benzyl bromide; With sulfur; at -78 - 20 ℃;

DOI:10.1016/j.tetlet.2006.07.056

upstream raw materials:

2-(benzylthio)benzoic acid

ethyl 2-(benzylthio)benzoate

o-hydroxymethyl thiophenol

benzyl chloride

Downstream raw materials:

1-(chloromethyl)-2-[(phenylmethyl)sulfanyl]benzene

(3-Dimethylaminopropyl)-2-benzylthio-benzoat

<2-Dimethylaminoethyl>-2--phenylacetat

2-(2-(benzylthio)phenyl)acetonitrile

Refernces

• 1、 Li, Yiming,Pu, Jiahua,Jiang, Xuefeng. "A highly efficient Cu-catalyzed S-transfer reaction: From amine to sulfide". supporting information. p. 2692 - 2695. Retrieved 2014/06/09.
• 2、 Ko, Jaeyoung,Ham, Jungyeob,Yang, Inho,Chin, Jungwook,Nam, Sang-Jip,Kang, Heonjoong. "A simple one-pot synthesis of hydroxylated and carboxylated aryl alkyl sulfides from various bromobenzenes". . p. 7101 - 7106. Retrieved 2007/10/03.