N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline

Base Information

• Chemical Name: N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline
• CAS No.: 1400001-66-2
• Molecular Formula: C₃₄H₄₇BrN₆O₈
• Molecular Weight: 747.687
• Mol file: 1400001-66-2.mol

Synonyms:N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline

Chemical Property of N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline

There total 5 articles about N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline methyl ester (1400001-64-0) → N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline (1400001-66-2)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 24h;

DOI:10.1002/hlca.201200136

Reference yield:

methyl N-(4-bromobenzoyl)-2-methylalanylprolinate (1400001-57-1) → N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline (1400001-66-2)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 3 h / 20 °C

2: dichloromethane / 27 h / 0 - 20 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 22 h / 20 °C

4: dichloromethane / 96 h / 0 - 20 °C

5: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 24 h / 20 °C

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1002/hlca.201200136

Reference yield:

N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)proline (1400001-62-8) → N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline (1400001-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 96 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 24 h / 20 °C

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1002/hlca.201200136

upstream raw materials:

methyl N-(4-bromobenzoyl)-2-methylalanylprolinate

N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)proline methyl ester

N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)proline

N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline methyl ester

Downstream raw materials:

N-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]proline

1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide

N-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]proline methyl ester