1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide

Base Information

Chemical Name:1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide
CAS No.:1400001-72-0
Molecular Formula:C₄₉H₇₄BrN₉O₉
Molecular Weight:1013.09
Hs Code.:

1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide

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Chemical Property of 1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide

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Technology Process of 1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide

There total 7 articles about 1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400001-66-2
N-{N-[N-(N-{N-[-N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}proline

: 1400001-72-0
1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 120 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 h / 20 °C

3: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/hlca.201200136

Reference yield:

: 1400001-68-4
N-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]proline methyl ester

: 1400001-72-0
1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 h / 20 °C

2: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/hlca.201200136

Reference yield:

: 177747-22-7
methyl N-(2,2-dimethyl-2H-azirin-3-yl)-L-prolinate

: 1400001-72-0
1-[N-(N-{N-[N-(N-{N-[N-(4-bromobenzoyl)-2-methylalanyl]prolyl}-2-methylalanyl)prolyl]-2-methylalanyl}prolyl)-2-methylalanyl]-N-hexylprolinamide

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran / 103 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 3 h / 20 °C

3: dichloromethane / 27 h / 0 - 20 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 22 h / 20 °C

5: dichloromethane / 96 h / 0 - 20 °C

6: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 24 h / 20 °C

7: tetrahydrofuran / 120 h / 0 - 20 °C

8: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 h / 20 °C

9: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/hlca.201200136