acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester

Base Information

• Chemical Name: acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester
• CAS No.: 930785-83-4
• Molecular Formula: C₂₀H₁₉NO₄
• Molecular Weight: 337.375
• Mol file: 930785-83-4.mol

Synonyms:acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester

Chemical Property of acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester

There total 5 articles about acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C20H19NO4 (1448036-38-1) → acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester (930785-83-4)

Guidance literature:

Lipase PS (Amano); In acetonitrile; for 24 - 288h; pH=7.2; Aqueous phosphate buffer; Resolution of racemate;

Reference yield:

acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester → 3-hydroxy-1-(4-methoxy-phenyl)-4-(3-vinyl-phenyl)-azetidin-2-one + acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester (930785-83-4)

Guidance literature:

With Lipase PS; In phosphate buffer; acetonitrile; at 20 ℃; for 74h; pH=7;

DOI:10.1021/jm061071x

Reference yield:

(4-methoxy-phenyl)-(3-vinyl-benzylidene)-amine → acetic acid 1-(4-methoxy-phenyl)-2-oxo-4-(3-vinyl-phenyl)-azetidin-3-yl ester (930785-83-4)

Guidance literature:

Multi-step reaction with 2 steps

1: i-Pr₂NEt / CH₂Cl₂ / 12 h / -78 - 20 °C

2: lipase PS / aq. phosphate buffer; acetonitrile / 74 h / 20 °C / pH 7

With Lipase PS; N-ethyl-N,N-diisopropylamine; In phosphate buffer; dichloromethane; acetonitrile;

DOI:10.1021/jm061071x

upstream raw materials:

3-ethenylbenzaldehyde

4-methoxy-aniline

C₂₀H₁₉NO₄

Downstream raw materials:

3-hydroxy-1-(4-methoxy-phenyl)-4-(3-vinyl-phenyl)-azetidin-2-one

3'-dephenyl-3'-(m-vinylphenyl)-4-deacetyl-4-(pent-4-enoyl)-7-O-triethylsilyl-2'-O-triisopropylsilylpaclitaxel

C₆₅H₈₇NO₁₄Si₂

C₅₀H₅₃NO₁₄