Technology Process of C20H16N2S2
There total 3 articles about C20H16N2S2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-2-tolylthiazole;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
With
zinc dichloro(N,N,N′,N′-tetramethylethylenediamine);
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 1h;
Inert atmosphere;
4-bromo-2-tolylthiazole;
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
tetrahydrofuran; hexane;
at 80 ℃;
for 24h;
Inert atmosphere;
DOI:10.1002/anie.201201265
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / chloroform / 18 h / 60 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 - 20 °C / Inert atmosphere
2.3: 24 h / 80 °C / Inert atmosphere
With
N-Bromosuccinimide; n-butyllithium;
In
tetrahydrofuran; hexane; chloroform;
DOI:10.1002/anie.201201265
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 - 20 °C / Inert atmosphere
2.3: 24 h / 80 °C / Inert atmosphere
With
n-butyllithium; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
DOI:10.1002/anie.201201265
