4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine

Base Information

• Chemical Name: 4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine
• CAS No.: 85958-14-1
• Molecular Formula: C₅H₇NS*C₁₁H₁₁ClN₂O₅S₃
• Molecular Weight: 496.053
• Mol file: 85958-14-1.mol

Synonyms:4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine

Chemical Property of 4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine

There total 9 articles about 4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-fluoroaniline (2106-02-7) → 4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine (85958-14-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) NaNO₂, HCl, 2.) CuCl₂*2H₂O, HOAc, SO₂ / 1.) H₂O, 2.) H₂O, RT

2: 90 percent / NH₃ / Ambient temperature

3: 87 percent / dimethylformamide / 30 h / 60 °C

4: 94 percent / fuming sulfuric acid (20percent SO₂), fuming HNO₃ / 2 h / 55 °C

5: 90 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 20 °C / 75.01 Torr

6: 91 percent / 2N aq. NaOH / methanol / 1 h / Ambient temperature

7: 1.) NaNO₂, HCl, HOAc, 2.) CuCl₂*2H₂O, HOAc, SO₂ / 1.) H₂O, 2.) H₂O

8: 92 percent / H₂O / 0.5 h / 100 °C

9: dioxane / 1 h / 85 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; sulfur dioxide; sulfur trioxide; ammonia; water; hydrogen; nitric acid; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00362a017

Reference yield:

C9H10ClFN2O2S (69156-31-6) → 4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine (85958-14-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 94 percent / fuming sulfuric acid (20percent SO₂), fuming HNO₃ / 2 h / 55 °C

2: 90 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 20 °C / 75.01 Torr

3: 91 percent / 2N aq. NaOH / methanol / 1 h / Ambient temperature

4: 1.) NaNO₂, HCl, HOAc, 2.) CuCl₂*2H₂O, HOAc, SO₂ / 1.) H₂O, 2.) H₂O

5: 92 percent / H₂O / 0.5 h / 100 °C

6: dioxane / 1 h / 85 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; sulfur dioxide; sulfur trioxide; water; hydrogen; nitric acid; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/jm00362a017

Reference yield:

C9H9ClFN3O4S (69156-32-7) → 4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine (85958-14-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 20 °C / 75.01 Torr

2: 91 percent / 2N aq. NaOH / methanol / 1 h / Ambient temperature

3: 1.) NaNO₂, HCl, HOAc, 2.) CuCl₂*2H₂O, HOAc, SO₂ / 1.) H₂O, 2.) H₂O

4: 92 percent / H₂O / 0.5 h / 100 °C

5: dioxane / 1 h / 85 °C

With hydrogenchloride; sodium hydroxide; sulfur dioxide; water; hydrogen; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/jm00362a017

upstream raw materials:

2-Aminomethylthiophene

4-chloro-2-fluoro-5-sulfamoylbenzenesulfonic acid dihydrate

2-chloro-4-fluoroaniline

4-Chlor-2-fluor-5-sulfamoylanilin