Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester

Base Information

Chemical Name:Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester
CAS No.:144707-54-0
Molecular Formula:C₃₀H₃₃F₃O₄S
Molecular Weight:546.651
Hs Code.:

Synonyms:Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester

Suppliers and Price of Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester

There total 13 articles about Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 144707-35-7
7-Keto-3-phenylsulfinyl-12,14-dimethoxyabieta-8,11,13-triene

: 407-25-0
trifluoroacetic anhydride

: 144707-54-0
Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester

Guidance literature:: With pyridine; In dichloromethane; for 5h; Ambient temperature;

Reference yield:

: 2065-27-2
methyl 2,6-dimethoxybenzoate

: 144707-54-0
Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 94 percent / diethyl ether / 0.17 h / Heating

2: 98 percent / glacial HOAc / 2 h / Heating

3: 97 percent / H₂ / 5percent Pd/C / diethyl ether / 19 h / 2068.6 Torr

4: KBr, 18-crown-6, m-CPBA / CH₂Cl₂ / 0.5 h / 0 °C

5: 1) Mg / 1) THF, 2) cooling, then reflux, 5 min

6: NaBH₄ / methanol / 0.2 h / 0 °C

7: 87 percent / PBr₃, pyridine / benzene / 3 h

8: 77 percent / 18-crown-6 / acetonitrile / 1 h / 60 °C

9: 1) LDA / 1) THF, hexane, -78 deg C, 5 min, 2) -78 deg C -> rt, 3 h

10: 41 percent / BF₃ / nitromethane / 2 h / -30 °C

12: 91 percent / m-CPBA / CH₂Cl₂ / 1 h / -78 °C

13: 82 percent / pyridine / CH₂Cl₂ / 5 h / Ambient temperature

With pyridine; sodium tetrahydroborate; 18-crown-6 ether; boron trifluoride; hydrogen; phosphorus tribromide; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium bromide; lithium diisopropyl amide; palladium on activated charcoal; In methanol; diethyl ether; nitromethane; dichloromethane; acetonitrile; benzene;

Reference yield:

: 16929-70-7
1,3-dimethoxy-2-(1-hydroxy-1-methylethyl)benzene

: 144707-54-0
Trifluoro-acetic acid (4aR,10aS)-7-isopropyl-6,8-dimethoxy-1,1,4a-trimethyl-2-phenylsulfanyl-1,4,4a,10a-tetrahydro-phenanthren-9-yl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 98 percent / glacial HOAc / 2 h / Heating

2: 97 percent / H₂ / 5percent Pd/C / diethyl ether / 19 h / 2068.6 Torr

3: KBr, 18-crown-6, m-CPBA / CH₂Cl₂ / 0.5 h / 0 °C

4: 1) Mg / 1) THF, 2) cooling, then reflux, 5 min

5: NaBH₄ / methanol / 0.2 h / 0 °C

6: 87 percent / PBr₃, pyridine / benzene / 3 h

7: 77 percent / 18-crown-6 / acetonitrile / 1 h / 60 °C

8: 1) LDA / 1) THF, hexane, -78 deg C, 5 min, 2) -78 deg C -> rt, 3 h

9: 41 percent / BF₃ / nitromethane / 2 h / -30 °C

11: 91 percent / m-CPBA / CH₂Cl₂ / 1 h / -78 °C

12: 82 percent / pyridine / CH₂Cl₂ / 5 h / Ambient temperature

With pyridine; sodium tetrahydroborate; 18-crown-6 ether; boron trifluoride; hydrogen; phosphorus tribromide; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium bromide; lithium diisopropyl amide; palladium on activated charcoal; In methanol; diethyl ether; nitromethane; dichloromethane; acetonitrile; benzene;