16929-70-7Relevant academic research and scientific papers
Total synthesis of agastaquinone, a diterpenoid quinone isolated from Agastache rugosa
Lee, Sangku,Yoo, Jisu,Jung, Jae-Kyung,Kim, Jae Nyoung,Yoon, Myeong Sik
supporting information, p. 134 - 138 (2020/10/02)
Agastaquinone is a tricyclic diterpenoid isolated from Agastache rugose. The first total synthesis of agastaquinone was accomplished based on intramolecular Friedel-Crafts acylation of aryl lactone followed by aromatization leading to the tricyclic phenol
SUBSTITUTED-N-HETEROARYL COMPOUNDS AND USES THEREOF
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Page/Page column 95, (2020/01/24)
The present disclosure relates generally to compounds useful for the treatment and/or enhancement of cognitive function and negative symptoms associated with central nervous system disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.
Cationic Polyene Cyclization for Taiwaniaquinoid Construction
Graham, Marlowe,Baker, Robert W.,McErlean, Christopher S. P.
, p. 908 - 913 (2017/02/15)
An acid-catalyzed polyene cyclization has been used to rapidly generate the 6/5/6-fused ring system of the taiwaniaquinoid natural products. The cis-fused diastereomer was formed selectively, which enabled a step-efficient synthesis of (±)-5-epi-taiwaniaq
BORON-CONTAINING SMALL MOLECULES
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Paragraph 0245, (2015/02/19)
This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds.
1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS
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Page/Page column 51, (2014/10/03)
Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:
Enantioselective total syntheses of (-)-taiwaniaquinone H and (-)-taiwaniaquinol B by iridium-catalyzed borylation and palladium-catalyzed asymmetric α-arylation
Liao, Xuebin,Stanley, Levi M.,Hartwig, John F.
supporting information; experimental part, p. 2088 - 2091 (2011/04/16)
We report a concise, enantioselective total synthesis of (-)-taiwaniaquinone H and the first enantioselective total synthesis of (-)-taiwaniaquinol B by a route that includes asymmetric palladium-catalyzed α-arylation of a ketone with an aryl bromide that
A simple and efficient total synthesis of (±)-danshexinkun A, a bioactive diterpenoid from Salvia miltiorrhiza
Moghaddam, Firouz Matloubi,Farimani, Mahdi Moridi
supporting information; experimental part, p. 540 - 542 (2010/10/02)
An efficient 12-step route for the synthesis of the diterpenoid quinone (±)-danshexinkun A in 23% overall yield from the corresponding highly substituted stilbene using a photocyclization strategy is described.
Approach to the synthesis of candelabrone and synthesis of 3,7-diketo-12-hydroxyabieta-8,11,13-triene
Burnell, Robert H.,Caron, Stephane
, p. 1446 - 1454 (2007/10/02)
An approach to the synthesis of aromatic diterpenes was tested for its generality.Phenylacetonitriles with increasing substitution on the aromatic ring were prepared and alkylated with geranyl bromide and the resulting dienes subjected to cationic cycliza
A New General Synthetic Approach to Diterpenes: Application to Syntheses of (+ -)-Taxodione and (+ -)-Royleanone.
Engler, Thomas A.,Sampath, Umashanker,Naganathan, Sriram,Velde, David Vander,Takusagawa, Fusao
, p. 5712 - 5727 (2007/10/02)
High-pressure Diels - Alder reactions of 1,3,3-trimethyl-2-vinyl-1-cyclohexenes 3a,b,i with substituted 1,4-benzoquinones afford, in good yield, highly functionalized tricyclic ring systems which are found in many classes of naturally occuring terpenes.Notably, the reactions of 3a are highly regio- and stereoselective.Efficient, formal syntheses of antitumor diterpenes (+ -)-taxodione and (+ -)-royleanone are reported, which demonstrate the practical application of this new strategy for the preparation of varied terpene systems.Of particular interest is that the high-pressure reactions are accelerated by mild Lewis acids and the regio- and stereoselectivity of these reactions is also improved under the combined high-pressure / Lewis acid conditions in comparison to the high-pressure conditions alone.Indeed, in the reaction of 3a with 2-methoxy-5-methyl-1,4-benzoquinone, ZnBr2 is required to effect the Diels-Alder reaction even at 12 kbar, and endo adduct 12c is formed stereoselectively in 90percent yield.In contrast, low-temperature Ti(IV)-catalyzed reactions of diene 3a with methoxy-substituted 1,4-benzoquinones at atmospheric pressure regioselectively produce dihydrobenzofurans 19 and 20, apparently via alkylation of the quinone Ti(IV) complex by the diene followed by the ring closure.
