(1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide

Base Information

Chemical Name:(1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide
CAS No.:192060-69-8
Molecular Formula:C₂₄H₄₃NO₃Si
Molecular Weight:421.696
Hs Code.:

Synonyms:(1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide

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Chemical Property of (1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide

Chemical Property:

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Technology Process of (1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide

There total 3 articles about (1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 93550-77-7
2-(triisopropylsilyloxy)ethyl iodide

: 192060-67-6
(1R,2R)-(-)-pseudoephedrinepropionamide

: 192060-69-8
(1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide

Guidance literature:: With lithium chloride; lithium diisopropyl amide;
DOI:10.1002/anie.200390325

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 192060-69-8
(1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / imidazole / dimethylformamide / 2 h / 0 °C

2.1: LiCl; i-PrNH₂; BuLi / tetrahydrofuran; various solvent(s) / -78 - 23 °C

2.2: 93 percent / tetrahydrofuran; various solvent(s) / 18 h / -78 - 0 °C

With 1H-imidazole; n-butyllithium; isopropylamine; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo015791h

Reference yield:

: 321-97-1,7009-81-6,90-83-5,6912-63-6
(1R,2R)-pseudoephedrine

: 192060-69-8
(1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / NEt₃ / CH₂Cl₂ / 0.33 h / 23 °C

2.1: LiCl; i-PrNH₂; BuLi / tetrahydrofuran; various solvent(s) / -78 - 23 °C

2.2: 93 percent / tetrahydrofuran; various solvent(s) / 18 h / -78 - 0 °C

With n-butyllithium; isopropylamine; triethylamine; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo015791h