93550-77-7

Upstream product

• 624-76-0 Iodoethanol 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 

Downstream Products

• 857280-60-5 [2-(2,5-difluoro-phenoxy)-ethoxy]-triisopropyl-silane 
• 912346-66-8 benzyl (3R,4R,5S)-4-[4-(2-methoxyethoxymethyl)phenyl]-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(2-triisopropylsilanyloxyethoxy)piperidine-1-carboxylate 
• 1134559-82-2 {2-[3-(t-butoxycarbonylaminomethyl)-4-cyanophenylimino]-2-[5-ethyl-2-fluoro-3-(2-triisopropylsilanyloxyethoxy)phenyl]-1-methylsulfanylethylidene}carbamic acid methyl ester 
• 944953-56-4 6-[(3R,4R,5S)-4-(4-methoxyphenyl)-1-(toluene-4-sulfonyl)-5-(2-triisopropylsilanyloxyethoxy)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine 
• 944953-77-9 benzyl (3R,4R,5S)-4-[4-(3-methoxypropoxy)phenyl]-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(2-trisopropylsilanyloxyethoxy)piperidine-1-carboxylate 
• 857275-08-2 tert-butyl (3R,4R)-3-{4-bromo-3-[isobutyryl-(2-triisopropylsilanyloxyethyl)amino]benzyloxy}-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate 
• 192060-69-8 (1'R,2'R,S)-N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N,2-dimethyl-4-[(triisopropylsilyl)oxy]butanamide 

Relevant academic research and scientific papers

Synthesis of the C3-C18 fragment of amphidinolides G and H

A synthesis of an amphidinolides G and H C3-C18 subunits is reported. The C10-C18 segment 4 was prepared by a Negishi cross-coupling, whereas the synthesis of the C3-C9 fragment 5 employed an asymmetric cyanosilylation as the key step. The two segments were coupled by lithiation of iodide 4 and trapping of the anion with amide 5. The allylic epoxide moiety could be synthesized from the protected anti- mesylate 22.