Ethyl 6,8-dichloro caprylate

Base Information

• Chemical Name: Ethyl 6,8-dichloro caprylate
• CAS No.: 41443-60-1
• Molecular Formula: C8H14 Cl2 O2
• Molecular Weight: 213.104
• Hs Code.: 2915900090
• Mol file: 41443-60-1.mol

Synonyms:6,8-Dichlorooctanoicacid

Chemical Property of Ethyl 6,8-dichloro caprylate

Chemical Property:

• Appearance/Colour: Colorless to yellowish transparent liquid
• Vapor Pressure: 0.00233mmHg at 25°C
• Refractive Index: n20/D 1.462(lit.)
• Boiling Point: 288.5ºC at 760 mmHg
• PKA: 4.73±0.10(Predicted)
• Flash Point: >230 °F
• PSA: 26.30000
• Density: 1.107 g/mL
• LogP: 3.34620

Purity/Quality:

99% ^*data from raw suppliers

6,8-Dichloro-octanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6,8-Dichloro-octanoic Acid is an Intermediate in the synthesis of α-Lipoic acid (L468750) and its derivatives. 6,8-Dichloro-octanoate is a Intermediate in the synthesis of α-Lipoic acid (L468750) and its derivatives.

Technology Process of Ethyl 6,8-dichloro caprylate

There total 5 articles about Ethyl 6,8-dichloro caprylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(+)-8-chloro-6-hydroxy-octanoic acid (90435-60-2) → (+)-6,8-dichloro-octanoic acid (41443-60-1)

Guidance literature:

With pyridine; sodium hydroxide; thionyl chloride; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; toluene;

Reference yield:

(-)-6,8-dichlorooctanoic acid → (+)-6,8-dichloro-octanoic acid (41443-60-1)

Guidance literature:

(-)-6,8-dichlorooctanoic acid; With sodium hydroxide; In 2-methoxy-ethanol; water; at 60 ℃; for 5h;

With sulfuric acid; In 2-methoxy-ethanol; water; pH=1 - 2;

Reference yield:

→ (+)-6,8-dichloro-octanoic acid (41443-60-1)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

(+)-8-chloro-6-hydroxy-octanoic acid

6,8-dichlorooctanoic acid ethyl ester

Downstream raw materials:

6,8-dichloro-octanoic acid

(-)-Dihydrolipoic acid

Refernces

• 1、 -. "(+) and (-)-8-chloro-6-sulfonyloxy-octanoic acid, its derivatives, and methods for making". . . Retrieved 2008/06/13.