1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate

Base Information

Chemical Name:1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate
CAS No.:1342278-90-3
Molecular Formula:CH₄O₃S*C₁₆H₁₄N₄O₂S
Molecular Weight:422.486
Hs Code.:

Synonyms:1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate

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Chemical Property of 1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate

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Technology Process of 1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate

There total 5 articles about 1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1342278-01-6
1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea

: 1342278-90-3
1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate

Guidance literature:: In methanol; acetone; at 80 ℃; for 0.25h; Inert atmosphere;

Reference yield:

: 5349-17-7
4-bromoacetylpyridine hydrobromide

: 1342278-90-3
1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 0.5 h / 100 °C / Microwave irradiation

2: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran; acetonitrile / 0.33 h / 100 °C / 11377.6 Torr / Microwave irradiation; Autoclave

4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Autoclave

5: acetone; methanol / 0.25 h / Inert atmosphere; Heating

With pyridine; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetone; acetonitrile;
DOI:10.1039/c2md00320a

Reference yield:

: 1342277-18-2
phenyl 4-(pyridin-4-yl)thiazol-2-ylcarbamate

: 1342278-90-3
1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; acetonitrile / 0.33 h / 100 °C / 11377.6 Torr / Microwave irradiation; Autoclave

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Autoclave

3: acetone; methanol / 0.25 h / Inert atmosphere; Heating

With triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1039/c2md00320a