tert-butyl [(trans-4-{[(2-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

Base Information

Chemical Name:tert-butyl [(trans-4-{[(2-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate
CAS No.:1165797-52-3
Molecular Formula:C₂₅H₃₃N₃O₃
Molecular Weight:423.555
Hs Code.:

Synonyms:tert-butyl [(trans-4-{[(2-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

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Chemical Property of tert-butyl [(trans-4-{[(2-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

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Technology Process of tert-butyl [(trans-4-{[(2-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

There total 2 articles about tert-butyl [(trans-4-{[(2-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1165799-93-8
C₁₉H₂₈BrN₃O₃

: 98-80-6
phenylboronic acid

: 1165797-52-3
tert-butyl [(trans-4-{[(2-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

Guidance literature:: With palladium diacetate; sodium hydrogencarbonate; In water; acetonitrile; at 150 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 66572-56-3
2-bromoisonicotinic acid

: 166168-16-7
trans-((4-aminomethyl)cyclohexylmethyl)carbamic acid tert-butyl ester

: 1165797-52-3
tert-butyl [(trans-4-{[(2-phenylisonicotinoyl)amino]methyl}cyclohexyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

2: palladium diacetate; sodium hydrogencarbonate / water; acetonitrile / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With palladium diacetate; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.04.014