2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline

Base Information

Chemical Name:2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline
CAS No.:1360546-91-3
Molecular Formula:C₃₉H₃₁F₂N₅O₂
Molecular Weight:639.704
Hs Code.:

Synonyms:2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline

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Chemical Property of 2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline

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Technology Process of 2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline

There total 6 articles about 2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1360546-86-6
C₃₂H₃₀F₂N₄

: 555-16-8
4-nitrobenzaldehdye

: 1360546-91-3
2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline

Guidance literature:: With 1,2,3-Benzotriazole; aluminum (III) chloride; In tetrahydrofuran; at 25 ℃; under air;
DOI:10.1002/ejoc.201101013

Reference yield:

: 83-34-1
3-Methylindole

: 1360546-91-3
2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / dimethyl sulfoxide / 25 °C

2: sodium hydroxide / dimethyl sulfoxide / 25 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 25 °C / 2327.23 Torr

4: 1,2,3-Benzotriazole; aluminum (III) chloride / tetrahydrofuran / 25 °C / under air

With 1,2,3-Benzotriazole; aluminum (III) chloride; palladium 10% on activated carbon; hydrogen; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1002/ejoc.201101013

Reference yield:

: 1360546-52-6
1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole

: 1360546-91-3
2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 25 °C / 2327.23 Torr

2: 1,2,3-Benzotriazole; aluminum (III) chloride / tetrahydrofuran / 25 °C / under air

With 1,2,3-Benzotriazole; aluminum (III) chloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol;
DOI:10.1002/ejoc.201101013