1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole

Base Information

• Chemical Name: 1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole
• CAS No.: 1360546-52-6
• Molecular Formula: C₃₂H₂₈F₂N₄O₂
• Molecular Weight: 538.597

Synonyms:1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole

Chemical Property of 1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole

Chemical Property:

Purity/Quality:

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Technology Process of 1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole

There total 3 articles about 1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H11FN2O2 (1360546-49-1) + 1-(4-fluorophenyl)methyl-piperazine (27469-60-9) → 1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole (1360546-52-6)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 25 ℃;

DOI:10.1002/ejoc.201101013

Reference yield:

3-Methylindole (83-34-1) → 1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole (1360546-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dimethyl sulfoxide / 25 °C

2: sodium hydroxide / dimethyl sulfoxide / 25 °C

With sodium hydroxide; In dimethyl sulfoxide;

DOI:10.1002/ejoc.201101013

Reference yield:

2,4-Difluoronitrobenzene (446-35-5) → 1-(5-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-nitrophenyl)-3-methyl-1H-indole (1360546-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dimethyl sulfoxide / 25 °C

2: sodium hydroxide / dimethyl sulfoxide / 25 °C

With sodium hydroxide; In dimethyl sulfoxide;

DOI:10.1002/ejoc.201101013

upstream raw materials:

3-Methylindole

C₁₅H₁₁FN₂O₂

1-(4-fluorophenyl)methyl-piperazine

2,4-Difluoronitrobenzene

Downstream raw materials:

C₃₂H₃₀F₂N₄

2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-6-(4-bromophenyl)-7-methylindolo[1,2-a]quinoxaline

2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-7-methyl-6-(4-nitrophenyl)indolo[1,2-a]quinoxaline

2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-6-(4-fluorophenyl)-7-methylindolo[1,2-a]quinoxaline

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