N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Chemical Name:N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide
CAS No.:913377-88-5
Molecular Formula:C₃₁H₃₀N₄O₄
Molecular Weight:522.604
Hs Code.:

Synonyms:N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Chemical Property of N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Technology Process of N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide

There total 3 articles about N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: 5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

: 913377-85-2
(4-aminophenyl)(7-methoxyquinolin-4-yl)methanol

: 913377-88-5
N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: With potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 13h;

Reference yield:

: 913377-84-1
(4-bromophenyl)-(7-methoxyquinolin-4-yl)methanol

: 913377-88-5
N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran; toluene / 3 h / 80 °C

2: potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 13 h / 20 - 60 °C

With potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 913377-88-5
N-(4-(hydroxy(7-(methyloxy)-4-quinolinyl)methyl)phenyl)-5-methyl-3-oxo-2-phenyl-1-propyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.5 h / -78 - 20 °C

1.2: 2 h / -78 - 20 °C

2.1: lithium hexamethyldisilazane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran; toluene / 3 h / 80 °C

3.1: potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 13 h / 20 - 60 °C

With potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; phenylmagnesium bromide; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene;