2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide

Base Information

• Chemical Name: 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide
• CAS No.: 1428673-21-5
• Molecular Formula: C₈H₇F₄NO₅S₂
• Molecular Weight: 337.273
• Mol file: 1428673-21-5.mol

Synonyms:2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide

Chemical Property of 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide

There total 2 articles about 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide (1428673-20-4) → 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide (1428673-21-5)

Guidance literature:

With dihydrogen peroxide; acetic acid; at 70 ℃; for 22h;

DOI:10.1016/j.bmc.2013.01.008

Reference yield:

pentafluorobenzenesulonyl chloride (832-53-1) → 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide (1428673-21-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide / 0.5 h / -10 °C / pH Ca_. 7

2: triethylamine / methanol / 8 h / Reflux

3: acetic acid; dihydrogen peroxide / 22 h / 70 °C

With ammonium hydroxide; dihydrogen peroxide; acetic acid; triethylamine; In methanol;

DOI:10.1016/j.bmc.2013.01.008

Reference yield: 88.0%

Cyclododecylamine (1502-03-0) + 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide (1428673-21-5) → 3-(cyclododecylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide (1604043-22-2)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 24h;

upstream raw materials:

pentafluorobenzenesulonyl chloride

2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide

Downstream raw materials:

3-(cyclododecylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide

3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide

3,5-bis[(3,4-dimethoxybenzyl)amino]-2,6-difluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide

3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide