2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide

Base Information

• Chemical Name: 2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide
• CAS No.: 1428673-20-4
• Molecular Formula: C₈H₇F₄NO₃S₂
• Molecular Weight: 305.274
• Mol file: 1428673-20-4.mol

Synonyms:2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide

Chemical Property of 2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide

There total 3 articles about 2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,3,4,5,6-pentafluorobenzenesulfonamide (778-36-9) + 2-hydroxyethanethiol (60-24-2) → 2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide (1428673-20-4)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 4h;

Reference yield: 41.0%

Cyclododecylamine (1502-03-0) + 2,3,5,6-tetrafluoro-4-[(2-phenylethyl)thio]benzenesulfonamide (1428673-32-8) → 2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide (1428673-20-4)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 60 ℃; for 16h;

DOI:10.1021/jm501003k

Reference yield:

pentafluorobenzenesulonyl chloride (832-53-1) → 2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)benzenesulfonamide (1428673-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / 0.5 h / -10 °C / pH Ca_. 7

2: triethylamine / methanol / 8 h / Reflux

With ammonium hydroxide; triethylamine; In methanol;

DOI:10.1016/j.bmc.2013.01.008

upstream raw materials:

2,3,4,5,6-pentafluorobenzenesulfonamide

2-hydroxyethanethiol

pentafluorobenzenesulonyl chloride

Cyclododecylamine

Downstream raw materials:

2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl] benzenesulfonamide

2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide

3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide

3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide