Technology Process of (6S,9S,12S,18S,21S,24S)-18-benzyl-21-((R)-1-hydroxyethyl)-24-(hydroxymethyl)-12-isopropyl-2,2,6,9-tetramethyl-4,7,10,13,16,19,22-heptaoxo-3-oxa-5,8,11,14,17,20,23-heptaazapentacosan-25-oic acid
There total 2 articles about (6S,9S,12S,18S,21S,24S)-18-benzyl-21-((R)-1-hydroxyethyl)-24-(hydroxymethyl)-12-isopropyl-2,2,6,9-tetramethyl-4,7,10,13,16,19,22-heptaoxo-3-oxa-5,8,11,14,17,20,23-heptaazapentacosan-25-oic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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1620162-01-7
(6S,9S,12S,18S,21S,24S)-18-benzyl-21-((R)-1-hydroxyethyl)-24-(hydroxymethyl)-12-isopropyl-2,2,6,9-tetramethyl-4,7,10,13,16,19,22-heptaoxo-3-oxa-5,8,11,14,17,20,23-heptaazapentacosan-25-oic acid
- Guidance literature:
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With
N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide;
at 20 ℃;
for 48h;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol501669n
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1620162-01-7
(6S,9S,12S,18S,21S,24S)-18-benzyl-21-((R)-1-hydroxyethyl)-24-(hydroxymethyl)-12-isopropyl-2,2,6,9-tetramethyl-4,7,10,13,16,19,22-heptaoxo-3-oxa-5,8,11,14,17,20,23-heptaazapentacosan-25-oic acid
- Guidance literature:
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Multi-step reaction with 2 steps
1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ol501669n
