(Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid

Base Information

Chemical Name:(Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid
CAS No.:115267-06-6
Molecular Formula:C₂₂H₃₂N₂O₄S
Molecular Weight:420.573
Hs Code.:

Synonyms:(Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid

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Chemical Property of (Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid

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Technology Process of (Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid

There total 11 articles about (Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115266-91-6
(Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

: 115267-06-6
(Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid

Guidance literature:: With potassium hydroxide; In methanol; at 23 ℃; for 6h;
DOI:10.1021/jm00117a028

Reference yield:

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 115267-06-6
(Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dimsylsodium / dimethylsulfoxide / 4 h / 25 °C

2: 2.8 g / diethyl ether

3: 99.6 percent / various solvent(s) / 3 h / 45 °C

4: 33 percent / triethylamine / CH₂Cl₂

5: 1 N KOH / methanol / 6 h / 23 °C

With potassium hydroxide; dimsylsodium; triethylamine; In methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00117a028

Reference yield:

: 75040-20-9
exo-3-allylnorcamphor

: 115267-06-6
(Z)-7-[(1S,2R,3R,4R)-3-(4-Dimethylamino-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: hydroxylamine hydrochloride, KOH / methanol / 0.5 h / 0 °C

2: 78.4 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

3: 1.97 g / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

4: 100 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 20 °C

5: HIO₄ / dioxane; H₂O / 4 h / 25 °C

6: dimsylsodium / dimethylsulfoxide / 4 h / 25 °C

7: 2.8 g / diethyl ether

8: 99.6 percent / various solvent(s) / 3 h / 45 °C

9: 33 percent / triethylamine / CH₂Cl₂

10: 1 N KOH / methanol / 6 h / 23 °C

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; dimsylsodium; hydroxylamine hydrochloride; periodic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm00117a028