Technology Process of 3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine
There total 4 articles about 3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
1,4-dioxane; water;
at 20 - 85 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate / acetonitrile / 3 h / 20 °C
2: sodium tris(acetoxy)borohydride; trifluoroacetic acid / dichloromethane / 3 h / 20 °C
3: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane; water / 16 h / 20 - 85 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium tris(acetoxy)borohydride; trifluoroacetic acid / dichloromethane / 3 h / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane; water / 16 h / 20 - 85 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane; water;