3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Base Information

Chemical Name:3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine
CAS No.:1429341-01-4
Molecular Formula:C₂₂H₁₆F₅NO
Molecular Weight:405.367
Hs Code.:

Synonyms:3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Chemical Property of 3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Technology Process of 3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine

There total 4 articles about 3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 957034-45-6
(2-methyl-4-(trifluoromethyl)phenyl)boronic acid

: 1429341-55-8
7-bromo-3-(2,6-difluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine

: 1429341-01-4
3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 20 - 85 ℃; for 16h; Inert atmosphere;

Reference yield:

: 56159-89-8
2-bromo-1-(2,6-difluorophenyl)ethanone

: 1429341-01-4
3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 3 h / 20 °C

2: sodium tris(acetoxy)borohydride; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 16 h / 20 - 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 1429341-54-7
2-(2-amino-5-bromophenoxy)-1-(2,6-difluoro-phenyl)-ethanone

: 1429341-01-4
3-(2,6-difluoro-phenyl)-7-(2-methyl-4-trifluoromethyl-phenyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 16 h / 20 - 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;