3-(2-chlorophenyl)-7-(5-methyl-2-(pyridin-3-yl)thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

Base Information

Chemical Name:3-(2-chlorophenyl)-7-(5-methyl-2-(pyridin-3-yl)thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine
CAS No.:1429341-36-5
Molecular Formula:C₂₃H₁₈ClN₃OS
Molecular Weight:419.934
Hs Code.:

Synonyms:3-(2-chlorophenyl)-7-(5-methyl-2-(pyridin-3-yl)thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-chlorophenyl)-7-(5-methyl-2-(pyridin-3-yl)thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2-chlorophenyl)-7-(5-methyl-2-(pyridin-3-yl)thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

There total 6 articles about 3-(2-chlorophenyl)-7-(5-methyl-2-(pyridin-3-yl)thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1279105-84-8
trifluoro-methanesulfonic acid 5-methyl-2-pyridin-3-yl-thiazol-4-yl ester

: 1429341-62-7
3-(2-chlorophenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

: 1429341-36-5
3-(2-chlorophenyl)-7-(5-methyl-2-(pyridin-3-yl)thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 95 ℃; for 2.5h;

Reference yield:

: 5000-66-8
2-chlorophenacyl bromide

: 1429341-36-5
3-(2-chlorophenyl)-7-(5-methyl-2-(pyridin-3-yl)thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 18 h / 20 °C

2: sodium tris(acetoxy)borohydride; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 3.5 h / 110 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 95 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 38191-34-3
2-amino-5-bromophenol

: 1429341-36-5
3-(2-chlorophenyl)-7-(5-methyl-2-(pyridin-3-yl)thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 18 h / 20 °C

2: sodium tris(acetoxy)borohydride; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 3.5 h / 110 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 95 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; acetonitrile;