38191-34-3

Basic information

• Product Name: 2-AMINO-5-BROMOPHENOL
• Synonyms: 2-AMino-5-broMphenol;4-Bromo-2-hydroxyaniline;2-AMINO-5-BROMOPHENOL;4-Bromo-2-hydroxylaniline;4-Bromo-2-hydroxylbenzenamine;2-Amino-5-bromophenol 99%
• CAS NO: 38191-34-3
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02
• Mol File: 38191-34-3.mol
• Article Data: 24

Chemical Properties

• Melting Point: 146-147 °C
• Boiling Point: 265.046 °C at 760 mmHg
• Flash Point: 114.096 °C
• Appearance: white to light yellow solid
• Density: 1.768 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.79±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-BROMOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-BROMOPHENOL(38191-34-3)
• EPA Substance Registry System: 2-AMINO-5-BROMOPHENOL(38191-34-3)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 38191-34-3(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow solid

InChI:InChI=1/C6H6BrNO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2

Upstream product

• 27684-84-0 5-bromo-2-nitrophenol 
• 7664-93-9 sulfuric acid 
• 10468-46-9 N-(4-bromophenyl)hydroxylamine 
• 95-55-6 2-amino-phenol 
• 5683-43-2 2-methyl-6-nitrobenzoxazole 
• 5676-60-8 6-amino-2-methylbenzoxazole 
• 16394-40-4 N-(4-bromo-2-hydroxyphenyl)acetamide 
• 106-40-1 4-bromo-aniline 
• 591-20-8 3-Bromophenol 
• 2101-88-4 1-azido-4-bromobenzene 
• 441019-63-2 2-amino-5-bromophenyl sulphate 
• 19932-85-5 6-bromobenzo[d]oxazol-2(3H)-one 

Downstream Products

• 96462-69-0 N-(4-bromo-2-hydroxy-phenyl)-N'-(3,4-dichloro-phenyl)-urea 
• 537029-51-9 6-bromo-2-(4-chlorobenzyl)benzoxazole 
• 116632-17-8 2-amino-3,5-dibromo-phenol 
• 151230-42-1 6-bromo-2- methylbenzo[d]oxazole 
• 1413929-84-6 C₁₄H₁₁BrClNO₂S 
• 1413930-02-5 C₁₄H₉BrClNO₂ 
• 1413929-71-1 C₁₄H₁₁BrClNO₃ 
• 1413929-91-5 C₁₄H₁₁BrClNO₂S 
• 1413930-07-0 C₁₄H₉BrClNO₂ 
• 537025-33-5 6-bromo-2-phenylbenzo[d]oxazole 
• 1415425-51-2 5-bromo-2-(pyrrole-2-yl-methylidine)aminophenol 
• 1200576-30-2 7-[4-(methylsulfonyl)phenyl]-3-piperidin-4-yl-3,4-dihydro-2H-1,4-benzoxazine. 
• 1200575-36-5 tert-butyl 4-{7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazin-3-yl}-piperidine-1-carboxylate 
• 1200575-40-1 3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate 

Relevant articles and documents

HMOX1 inducers

The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.

Synthesis of benzoxazoles via the copper-catalyzed hydroamination of alkynones with 2-aminophenols

We describe herein the synthetic method to benzoxazole derivatives via the copper-catalyzed hydroamination of alkynones with 2-aminophenols. The method produced a wide variety of functionalized benzoxazole derivatives in good yields. Preliminary mechanistic experiments revealed that the reaction would proceed through the copper-catalyzed hydroamination of alkynones and the sequential intramolecular cyclization of β-iminoketones/elimination of acetophenone promoted by the copper catalyst.

Ortho-aminophenol derivative and preparation method thereof

The invention first discloses a preparation method of an ortho-aminophenol derivative. The preparation method comprises the following steps: (1) by adopting an aryl amine compound as a substrate and 2-chloro-5-nitropyridine as a guiding base, reacting in acetonitrile, thus obtaining a pyridine aryl amine compound intermediate; (2) catalyzing the pyridine aryl amine compound intermediate in step (1) to make C-H activation reaction in a solvent by using iodobenzene diacetate as an oxidant and palladium acetate as a catalyst, thus obtaining an acetoxylation aniline derivative, draining, and thenperforming the chromatographic separation and purification; and (3) enabling the acetoxylation aniline derivative in step (2) to react in a tetrahydrofuran solvent for 30 min at a normal temperature by virtue of hydrazine hydrate, thus obtaining the ortho-aminophenol derivative, quenching, washing, extracting, drying, draining, and performing the chromatographic separation and purification. The invention also discloses the ortho-aminophenol derivative prepared by the method.