Technology Process of 6-ethyl-5-(2-phenyl-benzoxazol-6-yl)-3,6-dihydro-[1,3,4]thiadiazin-2-one
There total 5 articles about 6-ethyl-5-(2-phenyl-benzoxazol-6-yl)-3,6-dihydro-[1,3,4]thiadiazin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-bromo-1-(2-phenyl-benzoxazol-6-yl)butan-1-one; O-phenyl hydrazinecarbothioate;
With
triethylamine;
In
water; acetonitrile;
at 80 ℃;
for 1h;
With
toluene-4-sulfonic acid;
In
water; acetonitrile;
at 20 - 100 ℃;
Inert atmosphere;
microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boric acid / xylene / 144 h / Heating
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -70 °C / Inert atmosphere
2.2: 0.33 h / -70 °C
3.1: hydrogen bromide; acetic acid; pyridinium hydrobromide perbromide / 1 h / 20 °C
3.2: pH 8
4.1: triethylamine / acetonitrile; water / 1 h / 80 °C
4.2: 20 - 100 °C / Inert atmosphere; microwave irradiation
With
n-butyllithium; pyridinium hydrobromide perbromide; hydrogen bromide; boric acid; acetic acid; triethylamine;
In
tetrahydrofuran; hexane; water; acetonitrile; xylene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -70 °C / Inert atmosphere
1.2: 0.33 h / -70 °C
2.1: hydrogen bromide; acetic acid; pyridinium hydrobromide perbromide / 1 h / 20 °C
2.2: pH 8
3.1: triethylamine / acetonitrile; water / 1 h / 80 °C
3.2: 20 - 100 °C / Inert atmosphere; microwave irradiation
With
n-butyllithium; pyridinium hydrobromide perbromide; hydrogen bromide; acetic acid; triethylamine;
In
tetrahydrofuran; hexane; water; acetonitrile;
