537025-33-5

Usage

Uses

Used in Pharmaceutical Industry:
Benzoxazole, 6-bromo-2-phenylis used as a building block in the synthesis of various pharmaceuticals for its versatile chemical structure and reactivity. It contributes to the development of new drugs with improved therapeutic properties and efficacy.
Used in Agrochemical Industry:
In the agrochemical industry, Benzoxazole, 6-bromo-2-phenylis utilized as a key intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure and reactivity enable the creation of effective compounds for crop protection and management.
Used in Materials Science:
Benzoxazole, 6-bromo-2-phenylis used in materials science for its potential applications in the development of organic semiconductors. Its electronic properties and structural features make it a promising candidate for use in organic electronic devices, such as organic light-emitting diodes (OLEDs) and organic field-effect transistors (OFETs).
Used in Organic Synthesis:
Benzoxazole, 6-bromo-2-phenylis employed as a versatile building block in organic synthesis, allowing for the creation of a wide range of organic compounds with diverse applications. Its reactivity and structural features facilitate the synthesis of complex molecules for various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

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• 434-45-7 2,2,2-Trifluoroacetophenone 
• 855246-05-8 1-benzoylamino-2-benzoyloxy-4-bromo-benzene 
• 66416-72-6 4-bromo-2-iodoaniline 
• 698-16-8 benzohydroximoyl chloride 
• 106-40-1 4-bromo-aniline 
• 932-90-1 Benzaldoxime 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 27684-84-0 5-bromo-2-nitrophenol 
• 89598-96-9 (3-bromophenyl)boronic acid 

Relevant academic research and scientific papers

Anthracene, Triphenylene derivatives and organic electroluminescent device including the same

It provides an anthrasene or tripenylene derivatives that contribute to substantial light efficiency and viewing angle improvement of organic field-of-view light emitting elements. Organic field light emitting device according to the present invention, the first electrode; Second electrode; One or more organic layers disposed between the first electrode and the second electrode; And comprises a capping layer, the organic material layer or capping layer comprises an anthracene or tripenylene derivative represented by the following formula (1). [Formula 1] (In formula (in Formula 1, each subducer is as defined in the detailed description of the invention.)

Delivering 2-Aryl Benzoxazoles through Metal-Free and Redox-Neutral De-CF3Process

An unexpected cleavage of the Csp3-CF3 bond of CF3-hydrobenzoxazoles has been disclosed, affording a range of 2-aryl benzoxazoles under metal-free and redox-neutral conditions. This transformation has demonstrated broad substrate scope and good compatibility of functional groups. 2-Aryl benzothiazole and 2-aryl benzoimidazole could be smoothly assembled in the same manner. On the basis of preliminary mechanistic studies, base initiated and aromatization driven β-carbon elimination was considered to be the key step for the formation of 2. This reaction offers an alternative, facile, and sustainable route to access important 2-aryl benzoxazole motifs.

Acid-promoted cleavage of the C–C double bond of N-(2-Hydroxylphenyl)enaminones for the synthesis of benzoxazoles

An acid-mediated selective cleavage of C–C double bond of N-(2-hydroxylphenyl)enaminones with formation a new C–O bond for the synthesis of 2-substituted benzoxazoles has been developed. This protocol proceeds under transition metal- and oxidant-free conditions with broad functional group tolerance. The oxidative cleavage of C–C double bond of N-(2-hydroxylphenyl)enaminone is also realized using NCS or NFSI as oxidants with release of 2,2-dihalogen-acetophenone fragments.

A 2 - substituted benzoxazole derivative of the preparation method

The invention discloses a 2 - substituted benzoxazole derivative of the preparation method, its reaction as follows: . The present invention can be 2 - substituted pyrrole derivatives, acetophenone derivatives can be obtained and at the same time 2, 2 - dihalo acetophenone derivatives; and through the C (sp2 ) - C (sp2 ) At the same time selectively fracture of the aromatization. The method of the invention the resulting raw materials are easy, high yield, mild reaction conditions, the reaction time is short, wide substrate range, reaction specificity is strong, easy post treatment and green environmental protection.

Iodine Promoted One-Pot Synthesis of 2-Aryl Benzoxazoles from Amidoximes via Oxidative Cyclization and Ring Contraction

A molecular I2-promoted one-pot synthesis of 2-aryl benzoxazoles has been developed by using amidoximes rather than the limited 2-aminophenols or 2-haloamides as substrates. The amidoxime substrates provided unique and efficient strategies for converting readily available aniline and benzaldehyde precursors into valuable chemicals. This transformation proceeded smoothly under transition-metal-free conditions through a sequential oxidative cyclization and ring contraction, and provided a potential route for introducing certain groups at any site of the scaffold.

Aryl amine derivatieves and organic electroluminescent device including the same

Provided is an arylamine derivative effectively absorbing a high energy external light source of an ultraviolet (UV) region to minimize damage to organic materials in an organic electroluminescent device so as to contribute to substantial life extension o

Synthesis of benzoxazoles via the copper-catalyzed hydroamination of alkynones with 2-aminophenols

We describe herein the synthetic method to benzoxazole derivatives via the copper-catalyzed hydroamination of alkynones with 2-aminophenols. The method produced a wide variety of functionalized benzoxazole derivatives in good yields. Preliminary mechanistic experiments revealed that the reaction would proceed through the copper-catalyzed hydroamination of alkynones and the sequential intramolecular cyclization of β-iminoketones/elimination of acetophenone promoted by the copper catalyst.

Method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions

The invention discloses a method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions. According to the method, glacial aceticacid is taken as a catalyst; at solvent-free room temperature conditions, physical grinding is adopted, reaction of 2-substituted arylamines (2-mercapto arylamine, 2-aminophenol, and o-phenylenediamine) and aromatic aldehydes is carried out using physical grinding. The method is friendly to the environment, is simple in operation, is safe, is low in cost, and is high in efficiency. Compared withthe prior art, the advantages are that: the method is suitable for a large amount of functional groups, yield is high, less by-product is generated, operation is simple, the method is safe, cost is low, and the method is friendly to the environment.

Base-Free Selective O-Arylation and Sequential [3,3]-Rearrangement of Amidoximes with Diaryliodonium Salts: Synthesis of 2-Substituted Benzoxazoles

A variety of functionalized 2-substituted benzoxazoles can be prepared in good yields from amidoximes and diaryliodonium salts by selective O-arylation and sequential [3,3]-rearrangement under metal-free conditions. O-arylation of amidoximes was promoted by 3 ? molecule sieves in the absence of a base and a sequential TFA-mediated [3,3]-rearrangement was used to synthesize 2-substituted benzoxazoles. Both of the O-aryl products and rearrangement products were compatible with a broad range of sensitive functional groups such as ester, aldehyde, nitro, vinyl, amine, and amide groups in addition to halides. A bidentate N-ligand with double benzoxazoles was prepared at gram-scale in two steps. (Figure presented.).