3-p-tolylnaphthalen-1-amine

Base Information

• Chemical Name: 3-p-tolylnaphthalen-1-amine
• CAS No.: 121511-11-3
• Molecular Formula: C₁₇H₁₅N
• Molecular Weight: 233.313
• Mol file: 121511-11-3.mol

Synonyms:3-p-tolylnaphthalen-1-amine

Chemical Property of 3-p-tolylnaphthalen-1-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-p-tolylnaphthalen-1-amine

There total 4 articles about 3-p-tolylnaphthalen-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1-(2-[(4-methylphenyl)ethynyl]phenyl)ethanone (1262832-17-6) → 1-methyl-3-(p-tolyl)isoquinoline (352008-88-9) + 3-p-tolylnaphthalen-1-amine (121511-11-3)

Guidance literature:

With ammonia; silver trifluoromethanesulfonate; In methanol; at 120 ℃; for 0.75h; regioselective reaction; Microwave irradiation; sealed tube;

DOI:10.1039/c1ob06271a

Reference yield:

4-n-methylphenylacetylene (766-97-2) → 1-methyl-3-(p-tolyl)isoquinoline (352008-88-9) + 3-p-tolylnaphthalen-1-amine (121511-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trans-dichlorobis(triphenylphosphine)palladium(II); triethylamine / 0.25 h / 20 °C / Inert atmosphere

1.2: 6 h / 80 °C / Inert atmosphere

2.1: triphenylphosphine gold (I) chloride; ammonia; silver trifluoromethanesulfonate / methanol / 1 h / 120 °C / Microwave irradiation

With triphenylphosphine gold (I) chloride; trans-dichlorobis(triphenylphosphine)palladium(II); ammonia; silver trifluoromethanesulfonate; triethylamine; In methanol; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;

DOI:10.1039/c1ob06271a

Reference yield:

3-p-methylphenyl-1-tetralone (38425-35-3) → 3-p-tolylnaphthalen-1-amine (121511-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NH₂OH*HCl, sodium acetate / H₂O; ethanol / 0.25 h / Heating

2: 1.) acetic anhydride, 2.) HCl gas, 3.) NH₃ / 1.) acetic acid, 100 deg C, 10 min, 2.) 100 deg C, 1 h, 3.) H₂O

With hydrogenchloride; hydroxylamine hydrochloride; ammonia; sodium acetate; acetic anhydride; In ethanol; water;

upstream raw materials:

3-p-Tolyl-3,4-dihydro-2H-naphthalen-1-one oxime

3-p-methylphenyl-1-tetralone

1-(2-[(4-methylphenyl)ethynyl]phenyl)ethanone

4-n-methylphenylacetylene