8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-1-methyl-3,4-dihydro-1H-quinolin-2-one

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Chemical Name:8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-1-methyl-3,4-dihydro-1H-quinolin-2-one
CAS No.:80090-26-2
Molecular Formula:C₃₀H₃₆N₂O₆
Molecular Weight:520.626
Hs Code.:

Synonyms:8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-1-methyl-3,4-dihydro-1H-quinolin-2-one

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Chemical Property of 8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-1-methyl-3,4-dihydro-1H-quinolin-2-one

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Technology Process of 8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-1-methyl-3,4-dihydro-1H-quinolin-2-one

There total 6 articles about 8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-1-methyl-3,4-dihydro-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 65008-25-5
8-benzyloxy-5-(2,3-epoxypropoxy)-1-methyl-3,4-dihydrocarbostyril

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 80090-26-2
8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-1-methyl-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: In methanol; for 3h; Heating;
DOI:10.1248/cpb.29.2166

Reference yield:

: 59430-56-7
5,8-Dihydroxy-3,4-dihydro-2(1H)-quinolinone

: 80090-26-2
8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-1-methyl-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 48 percent / K₂CO₃ / acetone; H₂O / 4 h / Heating

2: 72.4 percent / p-toluenesulfonic acid / tetrahydrofuran

3: 65.4 percent / 50percent NaOH / dimethylformamide / 2 h / Ambient temperature

4: 87.5 percent / conc. HCl / methanol / 0.5 h / Ambient temperature

5: 55.8 percent / piperidine / 3 h / 90 - 100 °C

6: 51 percent / methanol / 3 h / Heating

With piperidine; hydrogenchloride; sodium hydroxide; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.29.2166

Reference yield:

: 59826-16-3
8-(Benzyloxy)-5-hydroxy-3,4-dihydro-2(1H)-quinolinone

: 80090-26-2
8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-1-methyl-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 72.4 percent / p-toluenesulfonic acid / tetrahydrofuran

2: 65.4 percent / 50percent NaOH / dimethylformamide / 2 h / Ambient temperature

3: 87.5 percent / conc. HCl / methanol / 0.5 h / Ambient temperature

4: 55.8 percent / piperidine / 3 h / 90 - 100 °C

5: 51 percent / methanol / 3 h / Heating

With piperidine; hydrogenchloride; sodium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.2166