[(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

Base Information

Chemical Name:[(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester
CAS No.:1196992-58-1
Molecular Formula:C₅₇H₅₈N₄O₇S₂
Molecular Weight:975.242
Hs Code.:

[(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

Synonyms:[(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

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Chemical Property of [(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

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Technology Process of [(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

There total 5 articles about [(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1196992-56-9
C₄₆H₄₄N₄O₇S

: 180973-24-4
(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid

: 1196992-58-1
[(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

Guidance literature:: C₄₆H₄₄N₄O₇S; With diethylamine; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

(E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 663918-95-4
(3S,4E)-3-hydroxy-1-((4R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanyl-hept-4-en-1-one

: 1196992-58-1
[(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

1.2: pH 2

2.1: diethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

With water; diethylamine; lithium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

: 167015-11-4
Fmoc-D-Cys(Trt)-OH

: 1196992-58-1
[(1-{(S)-2-[2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-acetylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamine / acetonitrile / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: diethylamine / dichloromethane; acetonitrile / 1.83 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: diethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

With diethylamine; In dichloromethane; acetonitrile;