1-(4-aminosulfonylphenyl)-3-(4-methylphenyl)-5-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-2-pyrazoline

Base Information

• Chemical Name: 1-(4-aminosulfonylphenyl)-3-(4-methylphenyl)-5-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-2-pyrazoline
• CAS No.: 1228954-21-9
• Molecular Formula: C₃₂H₂₉N₅O₂S
• Molecular Weight: 547.681
• Mol file: 1228954-21-9.mol

Synonyms:1-(4-aminosulfonylphenyl)-3-(4-methylphenyl)-5-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-2-pyrazoline

Chemical Property of 1-(4-aminosulfonylphenyl)-3-(4-methylphenyl)-5-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-2-pyrazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-aminosulfonylphenyl)-3-(4-methylphenyl)-5-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-2-pyrazoline

There total 3 articles about 1-(4-aminosulfonylphenyl)-3-(4-methylphenyl)-5-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-2-pyrazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(E)-1-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]-2-propen-1-one (1228954-10-6) + 4-aminosulfonylphenylhydrazine (4392-54-5) → 1-(4-aminosulfonylphenyl)-3-(4-methylphenyl)-5-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-2-pyrazoline (1228954-21-9)

Guidance literature:

With hydrogenchloride; In water; at 75 ℃;

DOI:10.1016/j.ejmech.2018.01.082

Reference yield: 55.0%

(E)-1-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]-2-propen-1-one (1228954-10-6) + 4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) → 1-(4-aminosulfonylphenyl)-3-(4-methylphenyl)-5-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-2-pyrazoline (1228954-21-9)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2010.01.059

Reference yield:

4-methylbenzaldehyde phenylhydrazone (2829-25-6) → 1-(4-aminosulfonylphenyl)-3-(4-methylphenyl)-5-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-2-pyrazoline (1228954-21-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.25 h

1.2: 5 h / 75 - 80 °C

2.1: sodium hydroxide / Reflux

3.1: hydrogenchloride / water / 75 °C

With hydrogenchloride; sodium hydroxide; trichlorophosphate; In water; 2.1: |Claisen-Schmidt Condensation;

DOI:10.1016/j.ejmech.2018.01.082

upstream raw materials:

(E)-1-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]-2-propen-1-one

4-hydrazinobenzene-1-sulfonamide hydrochloride

4-aminosulfonylphenylhydrazine

4-methylbenzaldehyde phenylhydrazone