2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

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Chemical Name:2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine
CAS No.:1418296-77-1
Molecular Formula:C₁₉H₁₄ClF₄N₃O
Molecular Weight:411.786
Hs Code.:

Synonyms:2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

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Chemical Property of 2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

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Technology Process of 2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

There total 6 articles about 2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1418297-45-6
3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

: 133457-49-5
6-chloro-α-methanesulfonyloxy-3-picoline

: 1418296-77-1
2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

Guidance literature:: With potassium tert-butylate; In 1,4-dioxane; at 0 - 20 ℃; for 16h;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418296-77-1
2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 °C

5.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

6.1: potassium tert-butylate / 1,4-dioxane / 16 h / 0 - 20 °C

With hydrogenchloride; oxalyl dichloride; potassium tert-butylate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418296-77-1
2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 °C

4.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

5.1: potassium tert-butylate / 1,4-dioxane / 16 h / 0 - 20 °C

With hydrogenchloride; oxalyl dichloride; potassium tert-butylate; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;