5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-N-methylpyridine-2-amine

Base Information

Chemical Name:5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-N-methylpyridine-2-amine
CAS No.:1418296-78-2
Molecular Formula:C₂₀H₁₈F₄N₄O
Molecular Weight:406.383
Hs Code.:

Synonyms:5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-N-methylpyridine-2-amine

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Chemical Property of 5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-N-methylpyridine-2-amine

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Technology Process of 5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-N-methylpyridine-2-amine

There total 7 articles about 5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-N-methylpyridine-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1418296-77-1
2-chloro-5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

: 74-89-5
methylamine

: 1418296-78-2
5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-N-methylpyridine-2-amine

Guidance literature:: In ethanol; at 145 ℃; for 7h; Microwave irradiation;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418296-78-2
5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-N-methylpyridine-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 °C

5.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

6.1: potassium tert-butylate / 1,4-dioxane / 16 h / 0 - 20 °C

7.1: ethanol / 7 h / 145 °C / Microwave irradiation

With hydrogenchloride; oxalyl dichloride; potassium tert-butylate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418296-78-2
5-[(3-{(Z)-2-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-N-methylpyridine-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 °C

4.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

5.1: potassium tert-butylate / 1,4-dioxane / 16 h / 0 - 20 °C

6.1: ethanol / 7 h / 145 °C / Microwave irradiation

With hydrogenchloride; oxalyl dichloride; potassium tert-butylate; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;