ammonium, 2-(R)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

Base Information

Chemical Name:ammonium, 2-(R)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate
CAS No.:1207989-14-7
Molecular Formula:C₄₁H₄₅ClN₂O₅S*H₃N
Molecular Weight:730.368
Hs Code.:

Synonyms:ammonium, 2-(R)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

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Chemical Property of ammonium, 2-(R)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

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Technology Process of ammonium, 2-(R)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

There total 14 articles about ammonium, 2-(R)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207989-12-5
sodium 2-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

: 1207989-13-6
ammonium, 2-(S)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

: 1207989-14-7
ammonium, 2-(R)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

Guidance literature:: With ammonium bicarbonate; In water; N,N-dimethyl-formamide; acetonitrile; Resolution of racemate;

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: 1207989-13-6
ammonium, 2-(S)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

: 1207989-14-7
ammonium, 2-(R)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

Guidance literature:: Multi-step reaction with 10 steps

1.1: dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate / tetrahydrofuran; ethanol; water / 0.08 h / 140 °C

2.1: AD mix-β; methanesulfonamide / water; tert-butyl alcohol / 96 h / 2 - 4 °C

3.1: tetrahydrofuran / Reflux; Inert atmosphere

4.1: triethyl phosphite / 150 °C / Reflux

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

6.1: lithium hydroxide; water / tetrahydrofuran; methanol / 5 h / 20 °C

7.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

7.2: 1.5 h / Reflux

8.1: hydrogenchloride / water; 1,4-dioxane / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

10.1: ammonium bicarbonate / N,N-dimethyl-formamide; acetonitrile

With hydrogenchloride; oxalyl dichloride; dichlorobis(tri-O-tolylphosphine)palladium; methanesulfonamide; AD mix-β; water; sodium carbonate; ammonium bicarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium hexamethyldisilazane; triethyl phosphite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1207989-44-3
[4-(4-tert-butylcyclohex-1-enyl)phenyl]acetic acid ethyl ester

: 1207989-13-6
ammonium, 2-(S)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

: 1207989-14-7
ammonium, 2-(R)-{4-[2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl]benzoylamino}ethanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: AD mix-β; methanesulfonamide / water; tert-butyl alcohol / 96 h / 2 - 4 °C

2.1: tetrahydrofuran / Reflux; Inert atmosphere

3.1: triethyl phosphite / 150 °C / Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

5.1: lithium hydroxide; water / tetrahydrofuran; methanol / 5 h / 20 °C

6.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

6.2: 1.5 h / Reflux

7.1: hydrogenchloride / water; 1,4-dioxane / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

9.1: ammonium bicarbonate / N,N-dimethyl-formamide; acetonitrile

With hydrogenchloride; oxalyl dichloride; methanesulfonamide; AD mix-β; water; ammonium bicarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium hexamethyldisilazane; triethyl phosphite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;