[4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester

Base Information

Chemical Name:[4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester
CAS No.:288627-04-3
Molecular Formula:C₁₆H₂₄F₄O₆P₂
Molecular Weight:450.304
Hs Code.:

Synonyms:[4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester

Suppliers and Price of [4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of [4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester

There total 10 articles about [4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 776-40-9
α,α’-dibromo-m-tetrafluoroxylene

: 122-52-1
triethyl phosphite

: 288627-04-3
[4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester

Guidance literature:: for 0.25h; Heating;
DOI:10.1016/S0022-1139(02)00289-0

Reference yield:

: 3217-47-8
2,3,5,6-tetrafluoroterephthalaldehyde

: 288627-04-3
[4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / (CH₃)2S*BH₃ / tetrahydrofuran / 0.25 h / 0 °C

2: 63 percent / PBr₃ / 1 h / Heating

3: 82 percent / 0.25 h / Heating

With dimethylsulfide borane complex; phosphorus tribromide; In tetrahydrofuran;
DOI:10.1016/S0022-1139(02)00289-0

Reference yield:

: 19842-76-3
2,3,5,6-tetrafluorobenzaldehyde

: 288627-04-3
[4-((diethoxyphosphoryl)methyl)-2,3,5,6-tetrafluorobenzyl]phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 g / p-TsOH / toluene / 2 h / Heating

2.1: n-BuLi / tetrahydrofuran / -25 °C

2.2: 76 percent / tetrahydrofuran / -25 - 20 °C

3.1: 72 percent / TFA; aq. HCl / 0.33 h / 55 °C

4.1: 83 percent / (CH₃)2S*BH₃ / tetrahydrofuran / 0.25 h / 0 °C

5.1: 63 percent / PBr₃ / 1 h / Heating

6.1: 82 percent / 0.25 h / Heating

With hydrogenchloride; n-butyllithium; dimethylsulfide borane complex; phosphorus tribromide; toluene-4-sulfonic acid; trifluoroacetic acid; In tetrahydrofuran; toluene;
DOI:10.1016/S0022-1139(02)00289-0