(S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

Base Information

Chemical Name:(S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester
CAS No.:77303-03-8
Molecular Formula:C₃₃H₄₃N₃O₁₀
Molecular Weight:641.719
Hs Code.:

(S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

Synonyms:(S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

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Chemical Property of (S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

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Technology Process of (S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

There total 3 articles about (S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 65671-48-9
(S)-2-((S)-2-Amino-propionylamino)-pentanedioic acid 5-benzyl ester 1-methyl ester; hydrochloride

: 77303-03-8
(S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 22h;
DOI:10.1021/jm00138a013

Reference yield:

: 65671-47-8
(S)-5-benzyl 1-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)pentanedioate

: 77303-03-8
(S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4 N HCl / dioxane / 1 h / Ambient temperature

2: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00138a013

Reference yield:

: 41089-47-8
L-glutamic acid α-methyl γ-benzyl diester hydrochloride

: 77303-03-8
(S)-2-[(S)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

2: 4 N HCl / dioxane / 1 h / Ambient temperature

3: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00138a013