(R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid benzyl ester

Base Information

• Chemical Name: (R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid benzyl ester
• CAS No.: 203640-02-2
• Molecular Formula: C₃₁H₂₆N₆O₄S
• Molecular Weight: 578.651

Synonyms:(R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid benzyl ester

Chemical Property of (R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid benzyl ester

Chemical Property:

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Technology Process of (R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid benzyl ester

There total 3 articles about (R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-bromophenyl)-2-phenyl-2H-tetrazole (99504-75-3) → (R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid benzyl ester (203640-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi, 2.) SO₂, 3.) SO₂Cl₂

2: N-methylmorpholine / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; n-butyllithium; sulfuryl dichloride; sulfur dioxide; In dichloromethane;

DOI:10.1021/jm9707582

Reference yield:

(R)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid benzyl ester (126090-33-3) → (R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid benzyl ester (203640-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / Ambient temperature

2: N-methylmorpholine / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; In dichloromethane;

DOI:10.1021/jm9707582

Reference yield:

4-(2-Phenyl-2H-tetrazol-5-yl)-benzenesulfonyl chloride (203639-66-1) + D-tryptophan benzyl ester trifluoroacetate → (R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid benzyl ester (203640-02-2)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; Ambient temperature;

DOI:10.1021/jm9707582

upstream raw materials:

4-(2-Phenyl-2H-tetrazol-5-yl)-benzenesulfonyl chloride

5-(4-bromophenyl)-2-phenyl-2H-tetrazole

(R)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid benzyl ester

Downstream raw materials:

(R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benzenesulfonylamino]-propionic acid

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