(S)-2-((2R,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester

Base Information

Chemical Name:(S)-2-((2R,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester
CAS No.:110221-38-0
Molecular Formula:C₂₇H₃₆N₂O₅S₂
Molecular Weight:532.725
Hs Code.:

Synonyms:(S)-2-((2R,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester

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Chemical Property of (S)-2-((2R,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester

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Technology Process of (S)-2-((2R,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester

There total 12 articles about (S)-2-((2R,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 110221-32-4
(S)-2-((2R,6R)-5-Oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester

: 110221-38-0
(S)-2-((2R,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 5h; Ambient temperature;
DOI:10.1021/jm00394a009

Reference yield:

: 90315-82-5
ethyl (R)-2-hydroxy-4-phenylbutyrate

: 110221-38-0
(S)-2-((2R,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 79 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 97 percent / NaH / dimethylformamide / 5 h / Ambient temperature

With pyridine; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a009

Reference yield:

: 34312-77-1
1-(2-thienyl)-2-nitroethene

: 110221-38-0
(S)-2-((2R,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / toluene / 16 h / Ambient temperature

2: 64 percent / H₂, AcOH / 5percent Pd/C / 5 h / 70 °C / 2280 Torr

3: 69 percent / diphenyl phosphorazidate, N-methylmorpholine / dimethylformamide / 16 h / Ambient temperature

4: 31 percent / 4 N aq. HCl / dioxane / 4 h / Ambient temperature

5: 79 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

6: 97 percent / NaH / dimethylformamide / 5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; diphenyl phosphoryl azide; hydrogen; sodium hydride; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00394a009