5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: 5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene
• CAS No.: 172937-62-1
• Molecular Formula: C₂₉H₃₂O₄Si
• Molecular Weight: 472.656

Synonyms:5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene

Chemical Property of 5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene

Chemical Property:

Purity/Quality:

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Technology Process of 5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene

There total 2 articles about 5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Hydroxy-1-tetralone (28315-93-7) → 5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene (172937-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide

2: NaH / toluene

With 1H-imidazole; sodium hydride; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2005.04.047

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene (172937-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide

2: NaH / toluene

With 1H-imidazole; sodium hydride; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2005.04.047

Reference yield: 86.0%

5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene (172937-62-1) → ethyl 5-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 25 ℃; for 3h;

DOI:10.1016/j.bmcl.2015.01.024

upstream raw materials:

5-Hydroxy-1-tetralone

tert-butylchlorodiphenylsilane

Downstream raw materials:

1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

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