1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Base Information

Chemical Name:1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene
CAS No.:172937-63-2
Molecular Formula:C₂₉H₃₄O₄Si
Molecular Weight:474.672
Hs Code.:

Synonyms:1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

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Chemical Property of 1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

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Technology Process of 1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

There total 1 articles about 1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 172937-62-1
5-t-butyldiphenylsilyloxy-2-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene

: 172937-63-2
1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2005.04.047

Reference yield: 92.0%

: 172937-63-2
1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

: 172937-64-3
2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-3,4-dihydronaphthalene

Guidance literature:: With potassium hydrogensulfate; In toluene;
DOI:10.1016/j.bmcl.2005.04.047

Reference yield:

: 172937-63-2
1-hydroxy-2-ethoxycarbonyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

: [5-(carboxymethoxy)-1,2,3,4-tetrahydro-2-naphthyl]methyl N,N-diphenylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / KHSO₄ / toluene

2: DIBAL-H / toluene

3: pyridine

4: tetrabutylammonium fluoride / tetrahydrofuran

5: K₂CO₃ / dimethylformamide

6: NaOH / ethanol; tetrahydrofuran

7: 71 percent / H₂ / Pd/C / ethanol; ethyl acetate

With pyridine; sodium hydroxide; potassium hydrogensulfate; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2005.04.047