2-Ethylhexyl salicylate

Base Information

• Chemical Name: 2-Ethylhexyl salicylate
• CAS No.: 118-60-5
• Molecular Formula: C15H22O3
• Molecular Weight: 250.338
• Hs Code.: 2918.21 DERIVATION
• NSC Number: 759240
• Mol file: 118-60-5.mol

Synonyms:Parsol EHS;Salicylic acid, 2-ethylhexyl ester;Solarom OS;Sunarome O;Sunarome WMO;Uvinul 0-18;2-Ethylhexylo-hydroxybenzoate;Dermoblock OS;Escalol 587;EusolexOS;NSC 46151;Neo Heliopan OS;Octisalate;Octyl salicylate;

Chemical Property of 2-Ethylhexyl salicylate

Chemical Property:

• Appearance/Colour: liquid
• Vapor Pressure: 8.07E-05mmHg at 25°C
• Refractive Index: 1.495 - 1.505
• Boiling Point: 331.5 °C at 760 mmHg
• PKA: 8.13±0.30(Predicted)
• Flash Point: 127.7 °C
• PSA: 46.53000
• Density: 1.035 g/cm³
• LogP: 3.76540
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Water Solubility.: 74.4μg/L at 20℃
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 250.15689456
• Heavy Atom Count: 18
• Complexity: 240

Purity/Quality:

99%min ^*data from raw suppliers

2-Ethylhexyl Salicylate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(CC)COC(=O)C1=CC=CC=C1O
• Isomeric SMILES: CCCC[C@@H](CC)COC(=O)C1=CC=CC=C1O
• Uses: Solvent for solid sunscreens. 2-ethylhexyl salicylate is also known as ethylhexyl salicylate and octyl salicylate. It is a uVB absorber. ethylhexyl salicylate is an FDA-approved uVB sunscreen chemical, it absorbs within the entire uVB range. It has an approved usage level of 3 to 5 percent in both the united States and the european union, and is a good solubilizer for benzophenone-3. In suntan lotions, it is used as a preservative and anti-microbial. This is a salt of salicylic acid occurring in wintergreen leaves and in other plants. It is also synthetically manufactured. It is considered a non-comedogenic raw material. This is the InCI name for octyl salicylate. octisalate is a uVB protector. This is the drug name for ethylhexyl salicylate and octyl salicylate.

Technology Process of 2-Ethylhexyl salicylate

There total 2 articles about 2-Ethylhexyl salicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-Ethylhexyl alcohol (104-76-7) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → 2-ethylhexyl salicylate (118-60-5)

Guidance literature:

With toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; at 150 ℃; Temperature; Flow reactor; High pressure; Green chemistry;

Reference yield:

→ 2-ethylhexyl salicylate (118-60-5)

Guidance literature:

Reference yield: 100.0%

iron(III) chloride + 2-ethylhexyl salicylate (118-60-5) → iron(III) octyl salicylate

Guidance literature:

In ethanol; at 20 ℃;

upstream raw materials:

2-Ethylhexyl alcohol

salicylic acid

Refernces

• 1、 -. "SKIN WHITENING AGENT CONTAINING NOVEL CYCLIC COMPOUND". Paragraph 0162; 0163. . Retrieved 2016/08/29.
• 2、 -. "PROCESS FOR TREATING SOL-GEL CAPSULES". . . Retrieved 2014/06/11.