Chemical Property of Pazufloxacin mesylate
Chemical Property:
- Appearance/Colour:crystalline solid
- Vapor Pressure:4E-12mmHg at 25°C
- Melting Point:>255 °C (dec.)
- Boiling Point:531.5 °C at 760 mmHg
- Flash Point:275.2 °C
- PSA：157.30000
- LogP:3.02510
- Storage Temp.:-20°C Freezer
- Solubility.:Aqueous Base (Slightly), DMSO (Slightly)
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:10
- Rotatable Bond Count:2
- Exact Mass:414.08970028
- Heavy Atom Count:28
- Complexity:695
- Purity/Quality:
-
99% *data from raw suppliers
Pazufloxacin mesylate *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi,
C,
F
- Hazard Codes:Xi,C,F
- Statements:
36/37/38-34-11
- Safety Statements:
26-45-36/37/39-16
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1COC2=C3N1C=C(C(=O)C3=CC(=C2C4(CC4)N)F)C(=O)O.CS(=O)(=O)O
- Isomeric SMILES:C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2C4(CC4)N)F)C(=O)O.CS(=O)(=O)O
- Recent ClinicalTrials:Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol
- Recent NIPH Clinical Trials:None
-
Description
This fluoroquinolone was co-developed by Toyama and
Mitsubishi Pharm and was launched for the intravenous
therapy of respiratory, urinary, surgical, gynecological and
systemic infections. Pazufloxacin is a broad-spectrum synthetic fluoroquinolone antibiotic. It is active against Gram-negative and Gram-positive bacteria, including clinical isolates of E. coli, K. pneumoniae, methicillin-susceptible and -resistant S. aureus, and methicillin-susceptible and -resistant S. epidermidis (MIC90s = 0.05, 0.1, 0.39, 12.5, 0.39, and 6.25 μg/ml, respectively). It inhibits E. coli, P. aeruginosa, and S. aureus DNA gyrase (IC50s = 0.88, 1.9, and 10.2 μg/ml, respectively) and S. aureus topoisomerase IV (IC50 = 24.2 μg/ml) in cell-free assays. In vivo, pazufloxacin is active against systemic E. coli, K. pneumoniae, and methicillin-resistant S. aureus infections in mice (ED50s = 0.15, 5.5, and 4.5 mg/kg, respectively).
-
Uses
A fluorinated quinolone antibiotic. Antibacterial.
