Technology Process of (1'S,2'S,3'R)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]adenine
There total 10 articles about (1'S,2'S,3'R)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]adenine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
18-crown-6 ether; potassium carbonate;
In
N,N-dimethyl-formamide;
at 110 ℃;
for 15h;
DOI:10.1021/jm00108a026
- Guidance literature:
-
Multi-step reaction with 9 steps
1: DCC / CH2Cl2 / Ambient temperature
2: imidazole / dimethylformamide / 1.5 h / 5 °C
3: N2O4, NaOAc / CCl4 / 0.25 h / 5 °C
4: LiBH4 / tetrahydrofuran / Ambient temperature
5: 83 g / pyridine / 2.5 h / Ambient temperature
6: 46.4 g / 0.5 N H2SO4 / acetonitrile / 17 h / Ambient temperature
7: 90 percent / LS-Selectride / tetrahydrofuran / 0.17 h / -78 °C
8: 84 percent / 8 h / 57 °C
9: 51 percent / K2CO3, 18-crown-6 / dimethylformamide / 15 h / 110 °C
With
pyridine; 1H-imidazole; lithium borohydride; 18-crown-6 ether; sulfuric acid; sodium acetate; dinitrogen tetraoxide; potassium carbonate; lithium tri-sec-butyl(hydrido)borate; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00108a026
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 92 percent / 2 N KOH / methanol / 1 h / 43 °C
2: DCC / CH2Cl2 / Ambient temperature
3: imidazole / dimethylformamide / 1.5 h / 5 °C
4: N2O4, NaOAc / CCl4 / 0.25 h / 5 °C
5: LiBH4 / tetrahydrofuran / Ambient temperature
6: 83 g / pyridine / 2.5 h / Ambient temperature
7: 46.4 g / 0.5 N H2SO4 / acetonitrile / 17 h / Ambient temperature
8: 90 percent / LS-Selectride / tetrahydrofuran / 0.17 h / -78 °C
9: 84 percent / 8 h / 57 °C
10: 51 percent / K2CO3, 18-crown-6 / dimethylformamide / 15 h / 110 °C
With
pyridine; 1H-imidazole; potassium hydroxide; lithium borohydride; 18-crown-6 ether; sulfuric acid; sodium acetate; dinitrogen tetraoxide; potassium carbonate; lithium tri-sec-butyl(hydrido)borate; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00108a026
