(1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine

Base Information

• Chemical Name: (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine
• CAS No.: 207344-94-3
• Molecular Formula: C₁₈H₁₉N₅O₃
• Molecular Weight: 353.381
• Mol file: 207344-94-3.mol

Synonyms:(1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine

Chemical Property of (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine

There total 2 articles about (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(1'S,2'S,3'R)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]adenine (132294-20-3) → (1α,2β,3α)-3-(6-amino-9H-purin-9-yl)-1,2-cyclobutanedimethanol (126187-01-7) + (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine (207344-94-3)

Guidance literature:

With phosphate buffer; Lipase MY; In acetone; for 144h; Product distribution; various solvents;

DOI:10.1016/S0040-4039(98)00282-2

Reference yield: 18.0%

(1'S,2'S,3'R)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]adenine (132294-20-3) → (1α,2β,3α)-3-(6-amino-9H-purin-9-yl)-1,2-cyclobutanedimethanol (126187-01-7) + (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine (207344-94-3) + (1'R,2'R,3'S)-9-{3'-benzoyloxymethyl-2'-hydroxymethylcyclobutyl}adenine

Guidance literature:

With phosphate buffer; Lipase MY; In acetonitrile; at 36 ℃; for 137h;

DOI:10.1016/S0040-4039(98)00282-2

Reference yield: 66.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine (207344-94-3) → (1'R,2'R,3'S)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}adenine (283598-20-9)

Guidance literature:

4,4'-dimethoxytrityl chloride; (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine; With pyridine; at 20 ℃; for 48h;

With sodium hydroxide; In 1,4-dioxane; methanol; water; at 20 ℃; for 12h;

DOI:10.1016/S0040-4020(00)00162-9

upstream raw materials:

(1'S,2'S,3'R)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]adenine

Downstream raw materials:

(1'R,2'R,3'S)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}adenine