2-methyl-6-(tert-butyldimethylsiloxy)-8-(p-toluenesulfonamido)quinoline

Base Information

Chemical Name:2-methyl-6-(tert-butyldimethylsiloxy)-8-(p-toluenesulfonamido)quinoline
CAS No.:1280679-80-2
Molecular Formula:C₂₃H₃₀N₂O₃SSi
Molecular Weight:442.654
Hs Code.:

Synonyms:2-methyl-6-(tert-butyldimethylsiloxy)-8-(p-toluenesulfonamido)quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-6-(tert-butyldimethylsiloxy)-8-(p-toluenesulfonamido)quinoline

Chemical Property:

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Technology Process of 2-methyl-6-(tert-butyldimethylsiloxy)-8-(p-toluenesulfonamido)quinoline

There total 4 articles about 2-methyl-6-(tert-butyldimethylsiloxy)-8-(p-toluenesulfonamido)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1280679-78-8
2-methyl-6-(tert-butyldimethylsiloxy)-8-aminoquinoline

: 98-59-9
p-toluenesulfonyl chloride

: 1280679-80-2
2-methyl-6-(tert-butyldimethylsiloxy)-8-(p-toluenesulfonamido)quinoline

Guidance literature:: With pyridine; In ethanol; at 0 - 20 ℃;
DOI:10.1021/ac200095f

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1280679-80-2
2-methyl-6-(tert-butyldimethylsiloxy)-8-(p-toluenesulfonamido)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0 - 20 °C

2.1: palladium 10% on activated carbon / ethanol / Inert atmosphere; Reflux

2.2: Inert atmosphere; Reflux

3.1: pyridine / ethanol / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/ac200095f

Reference yield:

: 257892-16-3
2-methyl-6-hydroxy-8-nitroquinoline

: 1280679-80-2
2-methyl-6-(tert-butyldimethylsiloxy)-8-(p-toluenesulfonamido)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0 - 20 °C

2.1: palladium 10% on activated carbon / ethanol / Inert atmosphere; Reflux

2.2: Inert atmosphere; Reflux

3.1: pyridine / ethanol / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/ac200095f