ethyl 4-(2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-ylethynyl)-2-fluorobenzoate

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Chemical Name:ethyl 4-(2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-ylethynyl)-2-fluorobenzoate
CAS No.:229961-36-8
Molecular Formula:C₂₃H₁₈F₄O₅S₂
Molecular Weight:514.519
Hs Code.:

Synonyms:ethyl 4-(2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-ylethynyl)-2-fluorobenzoate

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Chemical Property of ethyl 4-(2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-ylethynyl)-2-fluorobenzoate

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Technology Process of ethyl 4-(2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-ylethynyl)-2-fluorobenzoate

There total 10 articles about ethyl 4-(2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-ylethynyl)-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[N,N-bis(trifluoromethanesulfonyl)amino]-5-pyridine

aqueous NH₄ Cl: aqueous NH₄ Cl

: 229961-35-7
ethyl 4-<(2,2-dimethyl-4-oxothiochroman-6-yl)ethynyl>-2-fluorobenzoate

: 229961-36-8
ethyl 4-(2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-ylethynyl)-2-fluorobenzoate

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 696-63-9
4-Methoxybenzenethiol

: 229961-36-8
ethyl 4-(2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-ylethynyl)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 9 steps

1: 82 percent / piperidine / 32 h / 105 °C

2: (COCl)2 / benzene / 4 h / Ambient temperature

3: 78 percent / SnCl₄ / CH₂Cl₂ / 2 h / 0 °C

4: 40 percent / BBr₃ / CH₂Cl₂ / 5 h / 23 °C

5: 47 percent / pyridine / 4 h / 0 °C

6: 91 percent / Et₃N, CuI / Pd(PPh₃)2Cl₂ / dimethylformamide / 5 h / 95 °C

7: 99 percent / K₂CO₃ / methanol / Ambient temperature

8: 78 percent / Et₃N, CuI / Pd(PPh₃)2Cl₂ / Ambient temperature

9: 1.) NaN(TMS)2 / 1.) THF, -78 deg C, 30 min, 2.) THF, room temperature, overnight

With piperidine; pyridine; copper(l) iodide; oxalyl dichloride; sodium hexamethyldisilazane; boron tribromide; tin(IV) chloride; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(99)00055-3

Reference yield:

: 541-47-9
3-Methylbutenoic acid

: 229961-36-8
ethyl 4-(2,2-dimethyl-4-trifluorosulfonyloxy-(2H)-thiochromen-6-ylethynyl)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 9 steps

1: 82 percent / piperidine / 32 h / 105 °C

2: (COCl)2 / benzene / 4 h / Ambient temperature

3: 78 percent / SnCl₄ / CH₂Cl₂ / 2 h / 0 °C

4: 40 percent / BBr₃ / CH₂Cl₂ / 5 h / 23 °C

5: 47 percent / pyridine / 4 h / 0 °C

6: 91 percent / Et₃N, CuI / Pd(PPh₃)2Cl₂ / dimethylformamide / 5 h / 95 °C

7: 99 percent / K₂CO₃ / methanol / Ambient temperature

8: 78 percent / Et₃N, CuI / Pd(PPh₃)2Cl₂ / Ambient temperature

9: 1.) NaN(TMS)2 / 1.) THF, -78 deg C, 30 min, 2.) THF, room temperature, overnight

With piperidine; pyridine; copper(l) iodide; oxalyl dichloride; sodium hexamethyldisilazane; boron tribromide; tin(IV) chloride; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(99)00055-3