7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Base Information

Chemical Name:7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin
CAS No.:941587-21-9
Molecular Formula:C₂₇H₃₉N₅O₇S₃
Molecular Weight:641.834
Hs Code.:

Synonyms:7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

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Technology Process of 7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

There total 5 articles about 7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 941587-21-9
7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Guidance literature:

Reference yield:

: 7(S)-1′-N-(tert-butoxycarbonyl)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyl-2,3,4-tris-O-(trimethylsilyl)lincomycin

: 941587-21-9
7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Guidance literature:: With trifluoroacetic acid; at 0 - 20 ℃; for 0.5h;
DOI:10.1038/ja.2017.54

Reference yield:

: 663614-01-5
(2S,4R)-1-N-(tert-butoxycarbonyl)-4-n-pentylpyrrolidine-2-carboxylic acid

: 941587-21-9
7(S)-1′-demethyl-7-deoxy-4′-depropyl-7-{5-(2-nitrophenyl)-1,3,4-thiadiazol-2-ylthio}-4′-n-pentyllincomycin

Guidance literature:: Multi-step reaction with 5 steps

1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 23 h / 20 °C

2: 1,1,1,3,3,3-hexamethyl-disilazane; pyridine / 1 h / 20 °C

3: acetic acid / methanol / 2 h / 20 °C

4: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 20 °C

5: trifluoroacetic acid / 0.5 h / 0 - 20 °C

With pyridine; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1038/ja.2017.54